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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GSPT1 All Species: 39.7
Human Site: T120 Identified Species: 62.38
UniProt: P15170 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15170 NP_001123479.1 499 55756 T120 A K E K N R E T W Y L S W A L
Chimpanzee Pan troglodytes XP_001140542 404 45524 N73 G H K S F V P N M I G G A S Q
Rhesus Macaque Macaca mulatta XP_001107851 864 92841 T485 A K E K N R E T W Y L S W A L
Dog Lupus familis XP_536971 499 55716 T120 A K E K N R E T W Y L S W A L
Cat Felis silvestris
Mouse Mus musculus Q8R050 499 55692 T120 A K E K N R E T W Y L S W A L
Rat Rattus norvegicus Q6AXM7 679 74756 S301 S K K A G K A S F A Y A W V L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517098 414 45834 G86 S F V P N M I G G A S Q A D L
Chicken Gallus gallus NP_001129149 618 67640 T239 A K E K N R E T W Y L S W A L
Frog Xenopus laevis NP_001086960 553 61252 T174 A K E K N R E T W Y L S W A L
Zebra Danio Brachydanio rerio NP_942101 577 63652 T198 A K E K N R E T W Y L S W A L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477259 619 66434 S241 A R E K S R E S W Y L S W A L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P53013 463 50650 A109 M I T G T S Q A D C A V L V V
Sea Urchin Strong. purpuratus XP_785469 575 63867 S199 A K E K N R E S W Y L S W A L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P05453 685 76532 G306 A K D A G R Q G W Y L S W V M
Red Bread Mold Neurospora crassa Q01372 460 49654 S108 K N M I T G T S Q A D C A I L
Conservation
Percent
Protein Identity: 100 80.9 55 98.1 N.A. 98.5 32.5 N.A. 78.3 78.1 83.7 75.5 N.A. 57.5 N.A. 36 61.2
Protein Similarity: 100 80.9 56.1 98.8 N.A. 99 47.2 N.A. 81.1 78.9 87.3 80.5 N.A. 66.8 N.A. 53.3 74.2
P-Site Identity: 100 0 100 100 N.A. 100 20 N.A. 13.3 100 100 100 N.A. 80 N.A. 0 93.3
P-Site Similarity: 100 13.3 100 100 N.A. 100 60 N.A. 20 100 100 100 N.A. 100 N.A. 13.3 100
Percent
Protein Identity: N.A. N.A. N.A. N.A. 40.2 35.8
Protein Similarity: N.A. N.A. N.A. N.A. 54.1 52.7
P-Site Identity: N.A. N.A. N.A. N.A. 53.3 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 67 0 0 14 0 0 7 7 0 20 7 7 20 60 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 7 0 0 0 % C
% Asp: 0 0 7 0 0 0 0 0 7 0 7 0 0 7 0 % D
% Glu: 0 0 60 0 0 0 60 0 0 0 0 0 0 0 0 % E
% Phe: 0 7 0 0 7 0 0 0 7 0 0 0 0 0 0 % F
% Gly: 7 0 0 7 14 7 0 14 7 0 7 7 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 7 0 0 7 0 0 7 0 0 0 7 0 % I
% Lys: 7 67 14 60 0 7 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 67 0 7 0 80 % L
% Met: 7 0 7 0 0 7 0 0 7 0 0 0 0 0 7 % M
% Asn: 0 7 0 0 60 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 14 0 7 0 0 7 0 0 7 % Q
% Arg: 0 7 0 0 0 67 0 0 0 0 0 0 0 0 0 % R
% Ser: 14 0 0 7 7 7 0 27 0 0 7 67 0 7 0 % S
% Thr: 0 0 7 0 14 0 7 47 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 7 0 0 0 0 0 7 0 20 7 % V
% Trp: 0 0 0 0 0 0 0 0 67 0 0 0 74 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 67 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _