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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSPT1
All Species:
45.15
Human Site:
T139
Identified Species:
70.95
UniProt:
P15170
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15170
NP_001123479.1
499
55756
T139
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Chimpanzee
Pan troglodytes
XP_001140542
404
45524
K92
V
L
V
I
S
A
R
K
G
E
F
E
T
G
F
Rhesus Macaque
Macaca mulatta
XP_001107851
864
92841
T504
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Dog
Lupus familis
XP_536971
499
55716
T139
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8R050
499
55692
T139
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Rat
Rattus norvegicus
Q6AXM7
679
74756
T320
E
E
R
E
R
G
V
T
M
D
V
G
M
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517098
414
45834
F105
I
S
A
R
K
G
E
F
E
T
G
F
E
K
G
Chicken
Gallus gallus
NP_001129149
618
67640
T258
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Frog
Xenopus laevis
NP_001086960
553
61252
T193
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Zebra Danio
Brachydanio rerio
NP_942101
577
63652
T217
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477259
619
66434
T260
E
E
R
D
K
G
K
T
V
E
V
G
R
A
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P53013
463
50650
S128
G
E
F
E
A
G
I
S
K
N
G
Q
T
R
E
Sea Urchin
Strong. purpuratus
XP_785469
575
63867
T218
E
E
R
D
K
G
K
T
V
E
V
G
R
A
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P05453
685
76532
T325
E
E
R
N
D
G
K
T
I
E
V
G
K
A
Y
Red Bread Mold
Neurospora crassa
Q01372
460
49654
G127
G
T
G
E
F
E
A
G
I
S
K
D
G
Q
T
Conservation
Percent
Protein Identity:
100
80.9
55
98.1
N.A.
98.5
32.5
N.A.
78.3
78.1
83.7
75.5
N.A.
57.5
N.A.
36
61.2
Protein Similarity:
100
80.9
56.1
98.8
N.A.
99
47.2
N.A.
81.1
78.9
87.3
80.5
N.A.
66.8
N.A.
53.3
74.2
P-Site Identity:
100
6.6
100
100
N.A.
100
46.6
N.A.
13.3
100
100
100
N.A.
93.3
N.A.
13.3
100
P-Site Similarity:
100
20
100
100
N.A.
100
73.3
N.A.
20
100
100
100
N.A.
100
N.A.
26.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.2
35.8
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
54.1
52.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
73.3
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
93.3
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
7
7
0
0
0
0
0
0
67
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
60
7
0
0
0
0
7
0
7
0
0
0
% D
% Glu:
74
80
0
20
0
7
7
0
7
74
0
7
7
0
7
% E
% Phe:
0
0
7
0
7
0
0
7
0
0
7
7
0
0
14
% F
% Gly:
14
0
7
0
0
87
0
7
7
0
14
74
7
7
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
0
0
7
0
14
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
67
0
67
7
7
0
7
0
7
7
7
% K
% Leu:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
7
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
7
0
7
0
% Q
% Arg:
0
0
74
7
7
0
7
0
0
0
0
0
60
7
0
% R
% Ser:
0
7
0
0
7
0
0
7
0
7
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
0
0
74
0
7
0
0
14
7
7
% T
% Val:
7
0
7
0
0
0
7
0
60
0
74
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
60
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _