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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HPGD
All Species:
6.97
Human Site:
T259
Identified Species:
17.04
UniProt:
P15428
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15428
NP_000851.2
266
28977
T259
H
F
Q
D
Y
D
T
T
P
F
Q
A
K
T
Q
Chimpanzee
Pan troglodytes
XP_001157095
143
15515
Rhesus Macaque
Macaca mulatta
XP_001087715
266
28915
T259
H
F
Q
D
Y
D
A
T
P
F
Q
A
K
S
Q
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8VCC1
269
29162
S259
H
F
Q
D
Y
D
I
S
P
L
L
V
K
A
P
Rat
Rattus norvegicus
O08699
266
28921
F259
H
F
Q
D
Y
D
L
F
P
S
F
S
K
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086976
264
28708
R249
V
M
K
I
T
T
S
R
G
I
H
F
E
E
F
Zebra Danio
Brachydanio rerio
XP_694331
221
24242
Q212
K
Y
K
D
D
F
K
Q
R
M
D
K
Y
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54398
256
28980
Q224
M
P
E
E
A
A
M
Q
M
I
H
A
M
E
M
Honey Bee
Apis mellifera
XP_623818
263
28758
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796537
298
32477
I287
R
C
T
P
Q
N
G
I
D
Y
K
K
F
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
53.7
98.8
N.A.
N.A.
88.4
88.7
N.A.
N.A.
N.A.
68.8
46.9
N.A.
26.3
34.9
N.A.
36.9
Protein Similarity:
100
53.7
99.6
N.A.
N.A.
92.9
92.8
N.A.
N.A.
N.A.
81.9
62
N.A.
46.6
55.2
N.A.
56.3
P-Site Identity:
100
0
86.6
N.A.
N.A.
53.3
53.3
N.A.
N.A.
N.A.
0
6.6
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
0
93.3
N.A.
N.A.
60
60
N.A.
N.A.
N.A.
20
20
N.A.
20
0
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
10
0
0
0
0
30
0
20
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
50
10
40
0
0
10
0
10
0
0
0
10
% D
% Glu:
0
0
10
10
0
0
0
0
0
0
0
0
10
20
0
% E
% Phe:
0
40
0
0
0
10
0
10
0
20
10
10
10
0
10
% F
% Gly:
0
0
0
0
0
0
10
0
10
0
0
0
0
10
0
% G
% His:
40
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
10
10
0
20
0
0
0
0
0
% I
% Lys:
10
0
20
0
0
0
10
0
0
0
10
20
40
0
0
% K
% Leu:
0
0
0
0
0
0
10
0
0
10
10
0
0
0
0
% L
% Met:
10
10
0
0
0
0
10
0
10
10
0
0
10
0
10
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
10
0
0
0
0
40
0
0
0
0
0
20
% P
% Gln:
0
0
40
0
10
0
0
20
0
0
20
0
0
0
20
% Q
% Arg:
10
0
0
0
0
0
0
10
10
0
0
0
0
10
0
% R
% Ser:
0
0
0
0
0
0
10
10
0
10
0
10
0
10
0
% S
% Thr:
0
0
10
0
10
10
10
20
0
0
0
0
0
10
0
% T
% Val:
10
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
40
0
0
0
0
10
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _