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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HPGD All Species: 13.64
Human Site: T74 Identified Species: 33.33
UniProt: P15428 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P15428 NP_000851.2 266 28977 T74 D Q Q Q L R D T F R K V V D H
Chimpanzee Pan troglodytes XP_001157095 143 15515
Rhesus Macaque Macaca mulatta XP_001087715 266 28915 T74 D Q Q Q L R D T F R K V V D H
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q8VCC1 269 29162 T74 D Q K Q L R D T F R K V V D H
Rat Rattus norvegicus O08699 266 28921 T74 D Q K Q L R D T F R K V V D H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis NP_001086976 264 28708 A74 D Q K Q L K D A F R K T V E H
Zebra Danio Brachydanio rerio XP_694331 221 24242 V41 L V D L N Q S V G E E C K S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P54398 256 28980 M45 H R M E N V E M M K K L Q A I
Honey Bee Apis mellifera XP_623818 263 28758 V77 N I N E F E A V F K K V V N D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796537 298 32477 A114 S K D Q L E D A F S K T L E H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 53.7 98.8 N.A. N.A. 88.4 88.7 N.A. N.A. N.A. 68.8 46.9 N.A. 26.3 34.9 N.A. 36.9
Protein Similarity: 100 53.7 99.6 N.A. N.A. 92.9 92.8 N.A. N.A. N.A. 81.9 62 N.A. 46.6 55.2 N.A. 56.3
P-Site Identity: 100 0 100 N.A. N.A. 93.3 93.3 N.A. N.A. N.A. 66.6 0 N.A. 6.6 26.6 N.A. 40
P-Site Similarity: 100 0 100 N.A. N.A. 100 100 N.A. N.A. N.A. 86.6 13.3 N.A. 40 53.3 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 20 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % C
% Asp: 50 0 20 0 0 0 60 0 0 0 0 0 0 40 20 % D
% Glu: 0 0 0 20 0 20 10 0 0 10 10 0 0 20 0 % E
% Phe: 0 0 0 0 10 0 0 0 70 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 60 % H
% Ile: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 10 % I
% Lys: 0 10 30 0 0 10 0 0 0 20 80 0 10 0 0 % K
% Leu: 10 0 0 10 60 0 0 0 0 0 0 10 10 0 0 % L
% Met: 0 0 10 0 0 0 0 10 10 0 0 0 0 0 0 % M
% Asn: 10 0 10 0 20 0 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 50 20 60 0 10 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 10 0 0 0 40 0 0 0 50 0 0 0 0 0 % R
% Ser: 10 0 0 0 0 0 10 0 0 10 0 0 0 10 0 % S
% Thr: 0 0 0 0 0 0 0 40 0 0 0 20 0 0 0 % T
% Val: 0 10 0 0 0 10 0 20 0 0 0 50 60 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _