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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AREG
All Species:
16.36
Human Site:
S194
Identified Species:
45
UniProt:
P15514
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P15514
NP_001648.1
252
27895
S194
K
T
H
S
M
I
D
S
S
L
S
K
I
A
L
Chimpanzee
Pan troglodytes
XP_517224
252
27951
S194
K
T
H
S
M
I
D
S
S
L
S
K
I
A
L
Rhesus Macaque
Macaca mulatta
XP_001101978
252
28005
S194
K
T
H
S
M
I
D
S
S
L
S
K
I
A
L
Dog
Lupus familis
XP_532410
396
43657
S337
K
T
H
S
M
V
D
S
D
L
S
K
I
A
L
Cat
Felis silvestris
Mouse
Mus musculus
P31955
248
27531
K187
K
T
H
S
E
D
D
K
D
L
S
K
I
A
V
Rat
Rattus norvegicus
P24338
243
26615
S185
K
T
Q
K
K
D
D
S
D
L
S
K
I
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511015
221
24746
V171
F
S
N
T
A
L
A
V
V
A
V
L
V
S
V
Chicken
Gallus gallus
NP_001026708
210
23647
V165
T
V
L
V
V
V
A
V
L
L
S
S
I
S
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001104696
230
25617
G178
P
V
K
T
N
D
G
G
Y
D
R
T
T
A
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
96.4
52.7
N.A.
70.2
70.2
N.A.
50.7
42
N.A.
24.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.2
98.4
57.5
N.A.
81.3
80.1
N.A.
65
55.5
N.A.
44
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
66.6
66.6
N.A.
0
20
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
73.3
66.6
N.A.
46.6
40
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
12
0
23
0
0
12
0
0
0
78
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
34
67
0
34
12
0
0
0
0
0
% D
% Glu:
0
0
0
0
12
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% F
% Gly:
0
0
0
0
0
0
12
12
0
0
0
0
0
0
0
% G
% His:
0
0
56
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
34
0
0
0
0
0
0
78
0
0
% I
% Lys:
67
0
12
12
12
0
0
12
0
0
0
67
0
0
0
% K
% Leu:
0
0
12
0
0
12
0
0
12
78
0
12
0
0
67
% L
% Met:
0
0
0
0
45
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
12
0
12
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% R
% Ser:
0
12
0
56
0
0
0
56
34
0
78
12
0
23
0
% S
% Thr:
12
67
0
23
0
0
0
0
0
0
0
12
12
0
0
% T
% Val:
0
23
0
12
12
23
0
23
12
0
12
0
12
0
23
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _