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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TIMP2
All Species:
27.27
Human Site:
Y204
Identified Species:
54.55
UniProt:
P16035
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16035
NP_003246.1
220
24399
Y204
S
D
G
S
C
A
W
Y
R
G
A
A
P
P
K
Chimpanzee
Pan troglodytes
XP_001146829
234
25059
L219
S
I
A
S
S
H
C
L
Q
M
D
S
R
D
F
Rhesus Macaque
Macaca mulatta
Q95KL9
207
23229
Q200
E
P
G
L
C
T
W
Q
S
L
R
T
R
M
A
Dog
Lupus familis
XP_538410
211
24134
Y195
K
G
G
Y
C
S
W
Y
R
G
W
A
P
P
D
Cat
Felis silvestris
Mouse
Mus musculus
P25785
220
24310
Y204
S
D
G
S
C
A
W
Y
R
G
A
A
P
P
K
Rat
Rattus norvegicus
P30121
220
24338
Y204
S
D
G
S
C
A
W
Y
R
G
A
A
P
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515754
106
12074
E99
G
A
A
L
P
K
Q
E
F
L
D
I
E
D
P
Chicken
Gallus gallus
O42146
220
24294
Y204
S
D
G
S
C
A
W
Y
R
G
M
A
P
P
K
Frog
Xenopus laevis
O73746
214
24437
Y198
K
E
G
Y
C
S
W
Y
R
G
W
A
P
P
D
Zebra Danio
Brachydanio rerio
NP_878294
220
24449
Y204
G
D
G
S
C
A
W
Y
R
G
V
A
P
P
K
Tiger Blowfish
Takifugu rubipres
NP_001033040
220
24546
Y204
A
D
N
S
C
S
W
Y
R
G
V
S
S
P
K
Fruit Fly
Dros. melanogaster
Q9VH14
210
23961
C195
V
N
G
V
I
S
R
C
R
W
R
R
T
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
57.2
37.2
42.7
N.A.
97.2
98.1
N.A.
42.7
79
45
70.9
66.3
27.2
N.A.
N.A.
N.A.
Protein Similarity:
100
64
53.1
64.5
N.A.
99.5
99.5
N.A.
45.9
86.3
65.9
84.5
80.4
44.5
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
20
60
N.A.
100
100
N.A.
0
93.3
60
86.6
60
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
20
66.6
N.A.
100
100
N.A.
0
93.3
73.3
86.6
80
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
17
0
0
42
0
0
0
0
25
59
0
0
9
% A
% Cys:
0
0
0
0
75
0
9
9
0
0
0
0
0
0
0
% C
% Asp:
0
50
0
0
0
0
0
0
0
0
17
0
0
17
17
% D
% Glu:
9
9
0
0
0
0
0
9
0
0
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% F
% Gly:
17
9
75
0
0
0
0
0
0
67
0
0
0
0
0
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
9
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
17
0
0
0
0
9
0
0
0
0
0
0
0
0
50
% K
% Leu:
0
0
0
17
0
0
0
9
0
17
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
9
9
0
0
9
0
% M
% Asn:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
9
0
0
9
0
0
0
0
0
0
0
59
67
9
% P
% Gln:
0
0
0
0
0
0
9
9
9
0
0
0
0
9
0
% Q
% Arg:
0
0
0
0
0
0
9
0
75
0
17
9
17
0
0
% R
% Ser:
42
0
0
59
9
34
0
0
9
0
0
17
9
0
0
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
9
9
0
0
% T
% Val:
9
0
0
9
0
0
0
0
0
0
17
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
75
0
0
9
17
0
0
0
0
% W
% Tyr:
0
0
0
17
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _