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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB1
All Species:
29.7
Human Site:
Y346
Identified Species:
59.39
UniProt:
P16118
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16118
NP_002616.2
471
54681
Y346
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Chimpanzee
Pan troglodytes
XP_001158340
470
54094
Y345
Y
E
E
I
Q
D
N
Y
P
L
E
F
A
L
R
Rhesus Macaque
Macaca mulatta
XP_001091907
471
54591
Y346
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Dog
Lupus familis
XP_549023
589
67657
Y464
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Cat
Felis silvestris
Mouse
Mus musculus
P70266
471
54831
Y346
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Rat
Rattus norvegicus
P07953
471
54745
Y346
Y
E
E
I
Q
E
H
Y
P
E
E
F
A
L
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509392
470
54778
H345
Y
E
E
I
Q
E
H
H
P
E
E
F
A
L
R
Chicken
Gallus gallus
Q91348
470
54386
Y345
Y
E
E
I
Q
E
R
Y
P
E
E
F
A
L
R
Frog
Xenopus laevis
NP_001088535
470
54750
F345
Y
E
E
I
Q
E
N
F
P
E
E
F
A
L
R
Zebra Danio
Brachydanio rerio
XP_683102
465
54169
F340
Y
E
E
I
Q
E
H
F
P
E
E
F
A
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
Y342
Y
E
D
I
L
Q
R
Y
P
K
Q
A
D
D
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
D330
D
F
K
A
R
D
N
D
K
Y
E
Y
R
Y
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.5
98.5
78.7
N.A.
95.5
95.3
N.A.
90.8
79.8
82.1
78.3
N.A.
N.A.
N.A.
49.2
N.A.
Protein Similarity:
100
85.3
99.3
79.4
N.A.
97.4
97.2
N.A.
95.7
88.7
90.8
89.3
N.A.
N.A.
N.A.
67
N.A.
P-Site Identity:
100
80
100
100
N.A.
100
100
N.A.
93.3
93.3
86.6
93.3
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
100
93.3
100
100
N.A.
100
100
N.A.
100
93.3
100
100
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
44.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
64.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
0
0
0
9
84
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
0
0
17
0
9
0
0
0
0
9
9
0
% D
% Glu:
0
92
84
0
0
75
0
0
0
75
92
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
17
0
0
0
84
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
59
9
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
92
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
9
0
0
0
0
0
9
9
0
0
0
0
0
% K
% Leu:
0
0
0
0
9
0
0
0
0
9
0
0
0
84
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
25
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
92
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
84
9
0
0
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
9
0
17
0
0
0
0
0
9
0
100
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
92
0
0
0
0
0
0
67
0
9
0
9
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _