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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CREB1
All Species:
10
Human Site:
Y224
Identified Species:
22
UniProt:
P16220
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16220
NP_004370.1
341
36688
Y224
P
G
T
T
I
L
Q
Y
A
Q
T
T
D
G
Q
Chimpanzee
Pan troglodytes
XP_001139927
323
34734
V224
V
P
S
N
Q
V
V
V
Q
A
A
S
G
D
V
Rhesus Macaque
Macaca mulatta
XP_001092480
337
36119
Q226
Q
S
A
D
G
T
Q
Q
F
F
V
P
G
S
Q
Dog
Lupus familis
XP_860593
328
35246
S224
G
Q
Q
I
L
V
P
S
N
Q
V
V
V
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q01147
341
36656
Y224
P
G
T
T
I
L
Q
Y
A
Q
T
T
D
G
Q
Rat
Rattus norvegicus
P15337
341
36614
Y224
P
G
T
T
I
L
Q
Y
A
Q
T
T
D
G
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508739
318
34413
A220
S
Q
V
V
V
Q
A
A
T
G
D
M
P
T
Y
Chicken
Gallus gallus
NP_989781
327
35075
N224
Q
Q
I
L
V
P
S
N
Q
V
V
V
Q
A
A
Frog
Xenopus laevis
NP_001080072
324
34977
V224
L
V
P
S
N
Q
V
V
V
Q
A
A
S
G
D
Zebra Danio
Brachydanio rerio
NP_957203
318
33887
Q220
P
S
N
Q
V
V
V
Q
A
A
S
G
D
V
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VWW0
359
37920
N256
P
M
S
D
G
V
L
N
S
Q
L
A
G
T
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.7
66.2
96.1
N.A.
99.7
99.1
N.A.
62.4
94.7
90.3
85.3
N.A.
24.7
N.A.
N.A.
N.A.
Protein Similarity:
100
94.7
77.1
96.1
N.A.
100
100
N.A.
74.4
95.3
91.5
88.8
N.A.
37.5
N.A.
N.A.
N.A.
P-Site Identity:
100
0
13.3
6.6
N.A.
100
100
N.A.
0
0
13.3
26.6
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
13.3
20
N.A.
100
100
N.A.
6.6
6.6
20
46.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
10
10
37
19
19
19
0
10
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
19
0
0
0
0
0
0
10
0
37
10
10
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% F
% Gly:
10
28
0
0
19
0
0
0
0
10
0
10
28
37
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
10
28
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
0
10
10
28
10
0
0
0
10
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
10
10
10
0
0
19
10
0
0
0
0
0
0
% N
% Pro:
46
10
10
0
0
10
10
0
0
0
0
10
10
0
0
% P
% Gln:
19
28
10
10
10
19
37
19
19
55
0
0
10
10
46
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
19
19
10
0
0
10
10
10
0
10
10
10
10
0
% S
% Thr:
0
0
28
28
0
10
0
0
10
0
28
28
0
19
0
% T
% Val:
10
10
10
10
28
37
28
19
10
10
28
19
10
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
28
0
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _