KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CTLA4
All Species:
8.79
Human Site:
S194
Identified Species:
27.62
UniProt:
P16410
Number Species:
7
Phosphosite Substitution
Charge Score:
-0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16410
NP_001032720.1
223
24656
S194
S
K
M
L
K
K
R
S
P
L
T
T
G
V
Y
Chimpanzee
Pan troglodytes
XP_001173435
79
8836
R51
A
V
V
L
A
S
S
R
G
I
A
S
F
V
S
Rhesus Macaque
Macaca mulatta
Q8MJ02
201
21666
R173
C
L
T
W
K
G
P
R
R
Q
L
P
A
V
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P09793
223
24975
S194
S
K
M
L
K
K
R
S
P
L
T
T
G
V
Y
Rat
Rattus norvegicus
P31042
218
25152
N178
T
L
C
I
I
W
T
N
S
R
R
N
R
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514915
230
25841
S201
S
K
M
I
K
K
R
S
L
L
T
T
G
V
Y
Chicken
Gallus gallus
P31043
221
25383
Q176
A
V
F
I
I
Y
R
Q
K
S
K
R
N
R
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001343707
226
25142
I190
P
L
L
L
L
Y
I
I
L
I
I
T
S
C
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
31.8
24.6
N.A.
N.A.
74.4
27.7
N.A.
59.5
30.9
N.A.
22.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
34
40.3
N.A.
N.A.
84.7
41.7
N.A.
73.4
48.4
N.A.
42.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
13.3
13.3
N.A.
N.A.
100
0
N.A.
86.6
13.3
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
40
13.3
N.A.
N.A.
100
26.6
N.A.
93.3
26.6
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
0
0
13
0
0
0
0
0
13
0
13
0
0
% A
% Cys:
13
0
13
0
0
0
0
0
0
0
0
0
0
13
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
13
0
0
0
0
0
0
0
0
0
13
0
0
% F
% Gly:
0
0
0
0
0
13
0
0
13
0
0
0
38
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
38
25
0
13
13
0
25
13
0
0
0
0
% I
% Lys:
0
38
0
0
50
38
0
0
13
0
13
0
0
0
0
% K
% Leu:
0
38
13
50
13
0
0
0
25
38
13
0
0
13
13
% L
% Met:
0
0
38
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
13
0
0
0
13
13
0
0
% N
% Pro:
13
0
0
0
0
0
13
0
25
0
0
13
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
13
0
13
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
50
25
13
13
13
13
13
13
0
% R
% Ser:
38
0
0
0
0
13
13
38
13
13
0
13
13
0
25
% S
% Thr:
13
0
13
0
0
0
13
0
0
0
38
50
0
0
0
% T
% Val:
0
25
13
0
0
0
0
0
0
0
0
0
0
63
13
% V
% Trp:
0
0
0
13
0
13
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
25
0
0
0
0
0
0
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _