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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MGMT
All Species:
11.52
Human Site:
S199
Identified Species:
28.15
UniProt:
P16455
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16455
NP_002403
207
21646
S199
L
K
G
A
G
A
T
S
G
S
P
P
A
G
R
Chimpanzee
Pan troglodytes
XP_001142169
207
21582
S199
L
K
G
A
G
A
T
S
G
S
P
P
A
G
R
Rhesus Macaque
Macaca mulatta
XP_001089785
207
21935
S199
L
K
R
A
G
A
T
S
G
S
L
P
A
G
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P26187
211
22416
T203
L
K
S
S
F
E
S
T
S
S
E
P
S
G
R
Rat
Rattus norvegicus
P24528
209
22225
E201
S
W
L
K
P
S
F
E
S
S
S
P
K
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521529
115
12511
P108
S
R
P
T
G
S
G
P
A
P
T
S
P
D
P
Chicken
Gallus gallus
XP_421823
258
28080
E249
K
E
W
L
L
S
H
E
K
L
Q
K
E
K
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_684479
187
20183
L178
H
E
R
K
A
V
E
L
N
P
S
Q
S
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001191329
183
19555
W174
K
G
I
V
L
K
E
W
L
L
K
H
E
G
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P26188
188
21480
E180
Q
L
L
N
N
E
K
E
N
S
L
S
L
S
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.5
92.7
N.A.
N.A.
68.7
68.4
N.A.
36.2
42.2
N.A.
42
N.A.
N.A.
N.A.
N.A.
34.7
Protein Similarity:
100
98
94.1
N.A.
N.A.
77.2
77
N.A.
40.5
52.3
N.A.
55.5
N.A.
N.A.
N.A.
N.A.
50.2
P-Site Identity:
100
100
86.6
N.A.
N.A.
40
13.3
N.A.
6.6
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
86.6
N.A.
N.A.
66.6
20
N.A.
20
13.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
30
10
30
0
0
10
0
0
0
30
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% D
% Glu:
0
20
0
0
0
20
20
30
0
0
10
0
20
0
0
% E
% Phe:
0
0
0
0
10
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
20
0
40
0
10
0
30
0
0
0
0
60
0
% G
% His:
10
0
0
0
0
0
10
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
20
40
0
20
0
10
10
0
10
0
10
10
10
10
10
% K
% Leu:
40
10
20
10
20
0
0
10
10
20
20
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
10
10
0
0
0
20
0
0
0
0
0
0
% N
% Pro:
0
0
10
0
10
0
0
10
0
20
20
50
10
10
10
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% Q
% Arg:
0
10
20
0
0
0
0
0
0
0
0
0
0
0
50
% R
% Ser:
20
0
10
10
0
30
10
30
20
60
20
20
20
10
10
% S
% Thr:
0
0
0
10
0
0
30
10
0
0
10
0
0
0
0
% T
% Val:
0
0
0
10
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
10
10
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _