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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRLR
All Species:
4.55
Human Site:
S522
Identified Species:
10
UniProt:
P16471
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16471
NP_000940.1
622
69506
S522
V
N
K
D
G
A
L
S
L
L
P
K
Q
R
E
Chimpanzee
Pan troglodytes
XP_001149524
521
57934
K432
K
Q
R
E
N
S
G
K
P
K
K
P
G
T
P
Rhesus Macaque
Macaca mulatta
P79194
638
71309
M530
L
C
Q
E
D
F
I
M
D
N
A
Y
F
C
E
Dog
Lupus familis
XP_536502
677
75573
S577
V
N
K
D
G
A
L
S
L
L
P
K
Q
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q08501
608
68222
N517
L
L
P
K
Q
R
E
N
H
Q
T
E
N
P
G
Rat
Rattus norvegicus
P05710
610
68581
R517
L
S
L
F
P
K
Q
R
E
N
N
Q
T
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508625
625
69917
E530
A
L
L
P
K
R
K
E
D
P
G
Q
A
E
T
Chicken
Gallus gallus
Q04594
831
94084
Q726
E
V
H
K
V
I
R
Q
D
E
E
P
A
V
L
Frog
Xenopus laevis
NP_001079085
611
68297
A516
V
S
Q
N
N
A
L
A
L
I
P
K
H
N
E
Zebra Danio
Brachydanio rerio
NP_001122149
605
68870
P509
E
N
I
L
L
L
R
P
L
S
D
P
N
R
E
Tiger Blowfish
Takifugu rubipres
NP_001072093
510
57234
D419
V
D
V
G
T
H
L
D
H
I
E
A
D
S
S
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.5
23.5
68.2
N.A.
67.5
67.5
N.A.
58.8
39.2
45.8
34.7
30.3
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
83.7
40.5
77.6
N.A.
77.4
78.7
N.A.
71.6
51.5
61.4
52.5
47.4
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
6.6
93.3
N.A.
0
0
N.A.
0
0
46.6
26.6
13.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
33.3
100
N.A.
20
26.6
N.A.
6.6
0
80
26.6
26.6
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
28
0
10
0
0
10
10
19
0
0
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
10
0
% C
% Asp:
0
10
0
19
10
0
0
10
28
0
10
0
10
0
0
% D
% Glu:
19
0
0
19
0
0
10
10
10
10
19
10
0
19
46
% E
% Phe:
0
0
0
10
0
10
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
10
19
0
10
0
0
0
10
0
10
0
10
% G
% His:
0
0
10
0
0
10
0
0
19
0
0
0
10
0
0
% H
% Ile:
0
0
10
0
0
10
10
0
0
19
0
0
0
0
0
% I
% Lys:
10
0
19
19
10
10
10
10
0
10
10
28
0
10
10
% K
% Leu:
28
19
19
10
10
10
37
0
37
19
0
0
0
0
10
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
28
0
10
19
0
0
10
0
19
10
0
19
10
0
% N
% Pro:
0
0
10
10
10
0
0
10
10
10
28
28
0
10
10
% P
% Gln:
0
10
19
0
10
0
10
10
0
10
0
19
19
0
0
% Q
% Arg:
0
0
10
0
0
19
19
10
0
0
0
0
0
19
0
% R
% Ser:
0
19
0
0
0
10
0
19
0
10
0
0
0
10
10
% S
% Thr:
0
0
0
0
10
0
0
0
0
0
10
0
10
10
10
% T
% Val:
37
10
10
0
10
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _