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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
30.91
Human Site:
S509
Identified Species:
52.31
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
S509
E
I
N
K
F
H
F
S
D
L
P
L
T
E
L
Chimpanzee
Pan troglodytes
XP_518030
860
99527
S509
E
I
N
K
F
H
F
S
D
L
P
L
T
E
L
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
S509
E
I
N
K
F
H
F
S
D
L
P
L
T
E
L
Dog
Lupus familis
XP_543934
846
97567
S497
D
L
Y
E
F
R
F
S
D
F
P
I
S
E
H
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
S509
E
I
N
K
F
H
F
S
D
L
P
L
T
E
L
Rat
Rattus norvegicus
Q8VID6
935
104553
D614
A
I
D
D
I
H
F
D
D
F
S
L
D
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
S509
E
I
N
Q
F
H
F
S
D
L
P
L
T
E
L
Chicken
Gallus gallus
P52731
862
99990
S512
E
L
Y
E
F
R
F
S
D
F
P
V
T
E
H
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
C510
E
I
F
E
F
H
F
C
D
F
E
F
S
E
L
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
D568
G
I
D
K
L
S
F
D
D
F
S
L
D
V
D
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
T681
N
L
Y
S
F
T
F
T
D
F
E
L
V
D
D
Honey Bee
Apis mellifera
XP_394107
1016
115998
I616
N
L
Y
S
F
T
F
I
D
F
D
L
T
D
E
Nematode Worm
Caenorhab. elegans
P91119
710
81117
Y397
I
R
R
S
E
Q
K
Y
R
V
A
L
E
V
L
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
S568
K
L
Y
E
F
S
F
S
D
F
D
L
T
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
100
40
N.A.
100
33.3
N.A.
93.3
53.3
N.A.
53.3
33.3
26.6
33.3
13.3
46.6
P-Site Similarity:
100
100
100
73.3
N.A.
100
40
N.A.
100
73.3
N.A.
66.6
40
46.6
46.6
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
15
8
0
0
0
15
93
0
15
0
15
15
29
% D
% Glu:
50
0
0
29
8
0
0
0
0
0
15
0
8
65
8
% E
% Phe:
0
0
8
0
79
0
93
0
0
58
0
8
0
0
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
50
0
0
0
0
0
0
0
0
15
% H
% Ile:
8
58
0
0
8
0
0
8
0
0
0
8
0
0
0
% I
% Lys:
8
0
0
36
0
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
0
36
0
0
8
0
0
0
0
36
0
79
0
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
15
0
36
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% P
% Gln:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
8
0
0
15
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
22
0
15
0
58
0
0
15
0
15
0
0
% S
% Thr:
0
0
0
0
0
15
0
8
0
0
0
0
58
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
0
8
8
22
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
36
0
0
0
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _