KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
17.58
Human Site:
S58
Identified Species:
29.74
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
S58
S
P
S
S
M
E
E
S
E
I
I
F
D
L
L
Chimpanzee
Pan troglodytes
XP_518030
860
99527
S58
S
P
S
S
V
E
E
S
E
I
I
F
D
L
L
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
S58
S
P
S
S
V
E
E
S
E
I
I
F
D
L
L
Dog
Lupus familis
XP_543934
846
97567
A58
L
L
A
L
Q
E
E
A
G
S
A
E
P
A
V
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
S58
D
V
N
S
V
E
E
S
E
I
I
F
D
L
L
Rat
Rattus norvegicus
Q8VID6
935
104553
S60
P
A
L
A
G
A
S
S
L
A
Q
S
S
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
S58
T
L
T
S
A
E
E
S
E
I
V
F
E
L
L
Chicken
Gallus gallus
P52731
862
99990
E58
K
D
M
S
R
L
E
E
C
N
I
L
F
E
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
E58
H
E
L
S
S
M
E
E
C
E
I
I
F
D
M
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
K60
E
E
K
S
S
V
C
K
D
S
W
A
S
K
C
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
C235
S
A
S
S
L
P
E
C
R
R
H
L
M
D
L
Honey Bee
Apis mellifera
XP_394107
1016
115998
A121
Q
G
M
A
V
V
Q
A
K
S
P
L
K
N
I
Nematode Worm
Caenorhab. elegans
P91119
710
81117
F20
N
P
K
L
V
E
D
F
V
V
S
N
E
I
S
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
W62
S
P
Q
D
V
S
S
W
P
D
V
S
M
K
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
93.3
93.3
13.3
N.A.
73.3
6.6
N.A.
60
26.6
N.A.
20
6.6
33.3
0
13.3
20
P-Site Similarity:
100
100
100
33.3
N.A.
86.6
13.3
N.A.
86.6
26.6
N.A.
26.6
13.3
40
40
53.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
15
8
8
0
15
0
8
8
8
0
15
0
% A
% Cys:
0
0
0
0
0
0
8
8
15
0
0
0
0
0
8
% C
% Asp:
8
8
0
8
0
0
8
0
8
8
0
0
29
15
0
% D
% Glu:
8
15
0
0
0
50
65
15
36
8
0
8
15
8
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
36
15
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
8
0
0
0
0
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
36
43
8
0
8
8
% I
% Lys:
8
0
15
0
0
0
0
8
8
0
0
0
8
15
0
% K
% Leu:
8
15
15
15
8
8
0
0
8
0
0
22
0
36
58
% L
% Met:
0
0
15
0
8
8
0
0
0
0
0
0
15
0
8
% M
% Asn:
8
0
8
0
0
0
0
0
0
8
0
8
0
8
0
% N
% Pro:
8
36
0
0
0
8
0
0
8
0
8
0
8
0
0
% P
% Gln:
8
0
8
0
8
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
0
8
8
0
0
0
0
8
% R
% Ser:
36
0
29
65
15
8
15
43
0
22
8
15
15
0
8
% S
% Thr:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
0
43
15
0
0
8
8
15
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _