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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
30.3
Human Site:
S643
Identified Species:
51.28
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
S643
K
T
L
L
R
D
E
S
L
N
I
F
Q
N
L
Chimpanzee
Pan troglodytes
XP_518030
860
99527
S643
K
T
L
L
R
D
E
S
L
N
I
F
Q
N
L
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
S643
K
T
L
L
R
D
E
S
L
N
I
F
Q
N
L
Dog
Lupus familis
XP_543934
846
97567
S631
K
T
L
L
Q
D
E
S
L
N
I
F
Q
N
L
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
S643
K
T
L
L
R
D
E
S
L
N
I
F
Q
N
L
Rat
Rattus norvegicus
Q8VID6
935
104553
E748
A
V
M
I
L
Q
S
E
G
H
N
I
F
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
S643
K
T
L
L
K
D
E
S
L
N
I
F
Q
N
L
Chicken
Gallus gallus
P52731
862
99990
S646
K
T
L
L
Q
D
E
S
L
N
I
F
Q
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
A644
K
T
L
L
R
D
E
A
L
N
I
Y
Q
N
L
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
E702
A
V
M
I
L
Q
S
E
G
H
N
I
F
C
N
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
G815
V
M
I
L
N
S
E
G
N
N
I
F
Q
A
L
Honey Bee
Apis mellifera
XP_394107
1016
115998
S750
V
M
I
L
N
S
D
S
N
N
I
F
Q
S
L
Nematode Worm
Caenorhab. elegans
P91119
710
81117
D526
S
C
L
C
H
D
L
D
H
R
G
K
N
N
A
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
G702
I
M
I
L
N
S
E
G
N
N
I
F
E
F
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
100
93.3
N.A.
100
0
N.A.
93.3
93.3
N.A.
86.6
0
46.6
46.6
20
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
100
100
N.A.
100
20
53.3
66.6
20
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
0
0
0
8
0
0
0
0
0
15
8
% A
% Cys:
0
8
0
8
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
65
8
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
72
15
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
72
15
8
0
% F
% Gly:
0
0
0
0
0
0
0
15
15
0
8
0
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
8
15
0
0
0
0
0
% H
% Ile:
8
0
22
15
0
0
0
0
0
0
79
15
0
0
0
% I
% Lys:
58
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
0
65
79
15
0
8
0
58
0
0
0
0
0
72
% L
% Met:
0
22
15
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
0
0
22
0
0
0
22
79
15
0
8
65
15
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
15
15
0
0
0
0
0
0
72
0
0
% Q
% Arg:
0
0
0
0
36
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
22
15
58
0
0
0
0
0
8
0
% S
% Thr:
0
58
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
15
15
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _