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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
22.42
Human Site:
T690
Identified Species:
37.95
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
T690
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
E
W
Chimpanzee
Pan troglodytes
XP_518030
860
99527
T690
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
E
W
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
T690
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
E
W
Dog
Lupus familis
XP_543934
846
97567
K678
K
I
V
D
A
C
E
K
M
E
T
E
E
E
A
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
T690
K
I
V
D
Q
S
K
T
Y
E
S
T
Q
E
W
Rat
Rattus norvegicus
Q8VID6
935
104553
E786
L
Y
F
E
R
R
T
E
F
F
E
L
V
S
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
T690
K
I
V
D
Q
S
K
T
Y
E
S
E
Q
E
W
Chicken
Gallus gallus
P52731
862
99990
K693
K
I
V
D
A
I
E
K
M
E
T
E
E
E
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
T691
K
I
V
D
Q
S
K
T
Y
D
S
W
D
S
W
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
S740
L
Y
F
E
N
R
N
S
F
F
E
L
V
S
I
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
A852
M
Y
F
K
K
R
N
A
F
L
E
L
V
E
N
Honey Bee
Apis mellifera
XP_394107
1016
115998
K787
V
Y
F
K
K
K
N
K
F
M
E
L
I
D
E
Nematode Worm
Caenorhab. elegans
P91119
710
81117
I562
H
F
N
Q
T
V
T
I
L
Q
Q
D
G
H
N
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
D739
I
Y
F
K
K
R
A
D
F
F
K
L
V
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
100
46.6
N.A.
93.3
0
N.A.
100
46.6
N.A.
73.3
0
6.6
0
0
6.6
P-Site Similarity:
100
100
100
66.6
N.A.
93.3
20
N.A.
100
66.6
N.A.
80
20
20
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
15
0
8
8
0
0
0
0
0
0
15
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
58
0
0
0
8
0
8
0
8
8
8
0
% D
% Glu:
0
0
0
15
0
0
15
8
0
50
29
43
15
65
8
% E
% Phe:
0
8
36
0
0
0
0
0
36
22
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
58
0
0
0
8
0
8
0
0
0
0
8
0
8
% I
% Lys:
58
0
0
22
22
8
43
22
0
0
8
0
0
0
15
% K
% Leu:
15
0
0
0
0
0
0
0
8
8
0
36
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
15
8
0
0
0
0
0
% M
% Asn:
0
0
8
0
8
0
22
0
0
0
0
0
0
0
15
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
43
0
0
0
0
8
8
0
36
0
0
% Q
% Arg:
0
0
0
0
8
29
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
43
0
8
0
0
43
0
0
22
0
% S
% Thr:
0
0
0
0
8
0
15
43
0
0
15
8
0
0
0
% T
% Val:
8
0
58
0
0
8
0
0
0
0
0
0
29
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
43
% W
% Tyr:
0
36
0
0
0
0
0
0
43
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _