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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
10.91
Human Site:
T852
Identified Species:
18.46
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
T852
N
P
S
P
G
G
A
T
T
S
K
S
C
C
I
Chimpanzee
Pan troglodytes
XP_518030
860
99527
T852
N
P
S
P
G
G
A
T
T
S
K
S
C
C
I
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
T852
N
P
S
P
G
G
A
T
T
S
K
S
C
C
I
Dog
Lupus familis
XP_543934
846
97567
K839
G
G
G
V
D
D
K
K
S
K
T
C
L
M
L
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
A852
N
P
L
Q
G
A
P
A
S
K
S
C
C
I
Q
Rat
Rattus norvegicus
Q8VID6
935
104553
A928
V
P
S
S
P
S
P
A
V
A
G
E
D
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
T852
N
S
A
T
G
E
G
T
T
Q
S
K
S
C
S
Chicken
Gallus gallus
P52731
862
99990
G854
G
G
G
G
G
E
D
G
K
S
K
T
C
I
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
A850
G
N
S
V
Q
P
A
A
Q
S
K
T
C
V
I
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
C892
S
E
T
G
G
V
P
C
C
S
N
N
T
P
P
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
H1079
S
L
K
L
L
E
S
H
V
S
E
D
M
D
D
Honey Bee
Apis mellifera
XP_394107
1016
115998
V978
G
P
T
L
G
K
D
V
R
H
R
L
S
R
P
Nematode Worm
Caenorhab. elegans
P91119
710
81117
R703
Y
A
L
L
R
L
N
R
A
N
I
P
E
K
R
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
Q927
E
P
K
K
R
G
S
Q
M
S
Q
Q
C
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
100
0
N.A.
26.6
13.3
N.A.
33.3
26.6
N.A.
40
13.3
6.6
13.3
0
26.6
P-Site Similarity:
100
100
100
13.3
N.A.
33.3
26.6
N.A.
40
40
N.A.
46.6
33.3
26.6
26.6
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
0
0
8
29
22
8
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
8
0
0
15
50
29
0
% C
% Asp:
0
0
0
0
8
8
15
0
0
0
0
8
8
8
8
% D
% Glu:
8
8
0
0
0
22
0
0
0
0
8
8
8
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
29
15
15
15
58
29
8
8
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
15
29
% I
% Lys:
0
0
15
8
0
8
8
8
8
15
36
8
0
15
0
% K
% Leu:
0
8
15
22
8
8
0
0
0
0
0
8
8
0
15
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
8
8
0
% M
% Asn:
36
8
0
0
0
0
8
0
0
8
8
8
0
0
0
% N
% Pro:
0
50
0
22
8
8
22
0
0
0
0
8
0
8
15
% P
% Gln:
0
0
0
8
8
0
0
8
8
8
8
8
0
0
8
% Q
% Arg:
0
0
0
0
15
0
0
8
8
0
8
0
0
15
8
% R
% Ser:
15
8
36
8
0
8
15
0
15
58
15
22
15
0
8
% S
% Thr:
0
0
15
8
0
0
0
29
29
0
8
15
8
0
0
% T
% Val:
8
0
0
15
0
8
0
8
15
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _