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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
31.21
Human Site:
Y321
Identified Species:
52.82
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Chimpanzee
Pan troglodytes
XP_518030
860
99527
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Dog
Lupus familis
XP_543934
846
97567
Y308
I
F
Y
K
I
I
D
Y
I
L
H
G
K
E
E
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Rat
Rattus norvegicus
Q8VID6
935
104553
D395
A
L
L
E
V
V
N
D
L
F
E
E
Q
T
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
Y321
N
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Chicken
Gallus gallus
P52731
862
99990
Y323
N
F
Y
K
I
I
D
Y
I
L
H
G
K
E
E
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
Y322
I
F
Y
K
V
I
D
Y
I
L
H
G
K
E
D
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
F411
S
A
D
A
E
S
S
F
K
D
S
M
E
K
S
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
F514
R
N
R
F
T
V
L
F
E
L
G
G
E
Y
Q
Honey Bee
Apis mellifera
XP_394107
1016
115998
E454
N
K
F
T
T
I
F
E
M
D
N
E
T
Q
K
Nematode Worm
Caenorhab. elegans
P91119
710
81117
N244
A
V
I
I
K
V
M
N
F
A
Q
K
L
V
D
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
F399
N
D
V
K
N
I
S
F
L
K
G
F
E
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
100
80
N.A.
100
13.3
N.A.
100
86.6
N.A.
93.3
0
13.3
13.3
6.6
20
P-Site Similarity:
100
100
100
93.3
N.A.
100
46.6
N.A.
100
100
N.A.
93.3
26.6
33.3
40
13.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
8
0
8
0
0
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
0
58
8
0
15
0
0
0
0
58
% D
% Glu:
0
0
0
8
8
0
0
8
8
0
8
15
22
58
15
% E
% Phe:
0
58
8
8
0
0
8
22
8
8
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
15
65
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
58
0
0
0
0
% H
% Ile:
15
0
8
8
15
72
0
0
58
0
0
0
0
0
0
% I
% Lys:
0
8
0
65
8
0
0
0
8
8
0
8
58
8
8
% K
% Leu:
0
8
8
0
0
0
8
0
15
65
0
0
8
8
0
% L
% Met:
0
0
0
0
0
0
8
0
8
0
0
8
0
0
0
% M
% Asn:
58
8
0
0
8
0
8
8
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
8
8
8
% Q
% Arg:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
8
15
0
0
0
8
0
0
0
8
% S
% Thr:
0
0
0
8
15
0
0
0
0
0
0
0
8
8
8
% T
% Val:
0
8
8
0
50
22
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
58
0
0
0
0
58
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _