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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE6A All Species: 23.33
Human Site: Y475 Identified Species: 39.49
UniProt: P16499 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16499 NP_000431.2 860 99547 Y475 I L K T R E V Y G K E P W E C
Chimpanzee Pan troglodytes XP_518030 860 99527 Y475 I L K T R E V Y G K E P W E C
Rhesus Macaque Macaca mulatta XP_001107349 860 99509 Y475 I L K T R E V Y G K E P W E C
Dog Lupus familis XP_543934 846 97567 L462 I L K I K E K L N I D V I E D
Cat Felis silvestris
Mouse Mus musculus P27664 859 99628 Y475 I L K T R E V Y G K E P W E C
Rat Rattus norvegicus Q8VID6 935 104553 A577 S W A K Q S V A L D V L S Y H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506083 861 99448 Y475 I L K T R E V Y G K E P N E C
Chicken Gallus gallus P52731 862 99990 L477 I L K Y K E K L N V K S I E E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007161 858 99513 Y476 I L N T R E M Y D K E P D E C
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 S542 L S Y H A T C S K T E V D K F
Fruit Fly Dros. melanogaster Q9VFI9 1131 125621 Q658 H A T A S Q D Q T E K L T Q D
Honey Bee Apis mellifera XP_394107 1016 115998 S590 L S Y H A T A S N D D T L K L
Nematode Worm Caenorhab. elegans P91119 710 81117 A374 E D A F E I F A V Y C G L A L
Sea Urchin Strong. purpuratus NP_001029121 949 108476 L532 M A K Q Q V A L D V L S Y H A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.8 62.5 N.A. 94.6 25.4 N.A. 89.9 62.9 N.A. 77.2 25.1 24.3 23.2 23.3 33.1
Protein Similarity: 100 99.8 99.5 79.3 N.A. 96.7 45.3 N.A. 95.2 79.6 N.A. 87.3 44.5 40.9 42.1 43 53.3
P-Site Identity: 100 100 100 33.3 N.A. 100 6.6 N.A. 93.3 33.3 N.A. 73.3 6.6 0 0 0 6.6
P-Site Similarity: 100 100 100 46.6 N.A. 100 13.3 N.A. 93.3 46.6 N.A. 80 20 26.6 20 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 15 15 8 15 0 15 15 0 0 0 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 43 % C
% Asp: 0 8 0 0 0 0 8 0 15 15 15 0 15 0 15 % D
% Glu: 8 0 0 0 8 58 0 0 0 8 50 0 0 58 8 % E
% Phe: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 0 36 0 0 8 0 0 0 % G
% His: 8 0 0 15 0 0 0 0 0 0 0 0 0 8 8 % H
% Ile: 58 0 0 8 0 8 0 0 0 8 0 0 15 0 0 % I
% Lys: 0 0 58 8 15 0 15 0 8 43 15 0 0 15 0 % K
% Leu: 15 58 0 0 0 0 0 22 8 0 8 15 15 0 15 % L
% Met: 8 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 22 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 % P
% Gln: 0 0 0 8 15 8 0 8 0 0 0 0 0 8 0 % Q
% Arg: 0 0 0 0 43 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 15 0 0 8 8 0 15 0 0 0 15 8 0 0 % S
% Thr: 0 0 8 43 0 15 0 0 8 8 0 8 8 0 0 % T
% Val: 0 0 0 0 0 8 43 0 8 15 8 15 0 0 0 % V
% Trp: 0 8 0 0 0 0 0 0 0 0 0 0 29 0 0 % W
% Tyr: 0 0 15 8 0 0 0 43 0 8 0 0 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _