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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE6A
All Species:
26.06
Human Site:
Y501
Identified Species:
44.1
UniProt:
P16499
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16499
NP_000431.2
860
99547
Y501
E
L
P
D
A
D
K
Y
E
I
N
K
F
H
F
Chimpanzee
Pan troglodytes
XP_518030
860
99527
Y501
E
L
P
D
A
D
K
Y
E
I
N
K
F
H
F
Rhesus Macaque
Macaca mulatta
XP_001107349
860
99509
Y501
E
L
P
D
A
E
K
Y
E
I
N
K
F
H
F
Dog
Lupus familis
XP_543934
846
97567
V489
D
L
P
D
P
R
A
V
D
L
Y
E
F
R
F
Cat
Felis silvestris
Mouse
Mus musculus
P27664
859
99628
Y501
E
L
P
D
A
E
S
Y
E
I
N
K
F
H
F
Rat
Rattus norvegicus
Q8VID6
935
104553
L606
N
I
P
L
V
S
E
L
A
I
D
D
I
H
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506083
861
99448
Y501
E
L
P
D
P
E
Q
Y
E
I
N
Q
F
H
F
Chicken
Gallus gallus
P52731
862
99990
L504
E
L
P
D
P
K
D
L
E
L
Y
E
F
R
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001007161
858
99513
S502
V
L
P
D
S
E
E
S
E
I
F
E
F
H
F
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
L560
N
I
P
L
V
C
E
L
G
I
D
K
L
S
F
Fruit Fly
Dros. melanogaster
Q9VFI9
1131
125621
Y673
V
I
A
E
A
E
S
Y
N
L
Y
S
F
T
F
Honey Bee
Apis mellifera
XP_394107
1016
115998
Y608
P
I
P
S
A
E
S
Y
N
L
Y
S
F
T
F
Nematode Worm
Caenorhab. elegans
P91119
710
81117
K389
H
H
A
K
L
Y
D
K
I
R
R
S
E
Q
K
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
L560
C
V
P
S
A
R
E
L
K
L
Y
E
F
S
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.8
62.5
N.A.
94.6
25.4
N.A.
89.9
62.9
N.A.
77.2
25.1
24.3
23.2
23.3
33.1
Protein Similarity:
100
99.8
99.5
79.3
N.A.
96.7
45.3
N.A.
95.2
79.6
N.A.
87.3
44.5
40.9
42.1
43
53.3
P-Site Identity:
100
100
93.3
33.3
N.A.
86.6
26.6
N.A.
73.3
46.6
N.A.
53.3
26.6
26.6
33.3
0
26.6
P-Site Similarity:
100
100
100
60
N.A.
93.3
46.6
N.A.
93.3
60
N.A.
80
46.6
53.3
53.3
0
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
50
0
8
0
8
0
0
0
0
0
0
% A
% Cys:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
58
0
15
15
0
8
0
15
8
0
0
0
% D
% Glu:
43
0
0
8
0
43
29
0
50
0
0
29
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
79
0
93
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
8
8
0
0
0
0
0
0
0
0
0
0
0
50
0
% H
% Ile:
0
29
0
0
0
0
0
0
8
58
0
0
8
0
0
% I
% Lys:
0
0
0
8
0
8
22
8
8
0
0
36
0
0
8
% K
% Leu:
0
58
0
15
8
0
0
29
0
36
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
15
0
0
0
0
0
0
0
15
0
36
0
0
0
0
% N
% Pro:
8
0
86
0
22
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
8
0
8
0
% Q
% Arg:
0
0
0
0
0
15
0
0
0
8
8
0
0
15
0
% R
% Ser:
0
0
0
15
8
8
22
8
0
0
0
22
0
15
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% T
% Val:
15
8
0
0
15
0
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
50
0
0
36
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _