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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE6A All Species: 22.12
Human Site: Y527 Identified Species: 37.44
UniProt: P16499 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16499 NP_000431.2 860 99547 Y527 K C G I Q M Y Y E L K V V D K
Chimpanzee Pan troglodytes XP_518030 860 99527 Y527 K C G I Q M Y Y E L K V V D K
Rhesus Macaque Macaca mulatta XP_001107349 860 99509 Y527 K C G I Q M Y Y E L K V V D K
Dog Lupus familis XP_543934 846 97567 F515 K C G L R L F F E I N V V E K
Cat Felis silvestris
Mouse Mus musculus P27664 859 99628 Y527 K C G I Q M Y Y E L R V W D K
Rat Rattus norvegicus Q8VID6 935 104553 M632 T A A L R M F M E L G M V Q K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506083 861 99448 Y527 K C G I Q M Y Y E L K V V D K
Chicken Gallus gallus P52731 862 99990 F530 T C G I R L F F E I N V V E K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001007161 858 99513 Y528 K C G I K M Y Y E L G V V D K
Tiger Blowfish Takifugu rubipres Q1KKS3 903 102001 I586 T A A L R M F I E L G M V Q K
Fruit Fly Dros. melanogaster Q9VFI9 1131 125621 M699 R A V L R M F M Q C N L V S Q
Honey Bee Apis mellifera XP_394107 1016 115998 K634 R A T I R M F K Q C D L I Q K
Nematode Worm Caenorhab. elegans P91119 710 81117 V415 S V C N A D E V N K L K K I E
Sea Urchin Strong. purpuratus NP_001029121 949 108476 I586 Q G T L R M F I E C N L I E K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 98.8 62.5 N.A. 94.6 25.4 N.A. 89.9 62.9 N.A. 77.2 25.1 24.3 23.2 23.3 33.1
Protein Similarity: 100 99.8 99.5 79.3 N.A. 96.7 45.3 N.A. 95.2 79.6 N.A. 87.3 44.5 40.9 42.1 43 53.3
P-Site Identity: 100 100 100 46.6 N.A. 86.6 33.3 N.A. 100 46.6 N.A. 86.6 33.3 13.3 20 0 20
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 60 N.A. 100 86.6 N.A. 93.3 60 60 60 6.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 29 15 0 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 58 8 0 0 0 0 0 0 22 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 8 0 0 0 0 8 0 0 43 0 % D
% Glu: 0 0 0 0 0 0 8 0 79 0 0 0 0 22 8 % E
% Phe: 0 0 0 0 0 0 50 15 0 0 0 0 0 0 0 % F
% Gly: 0 8 58 0 0 0 0 0 0 0 22 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 58 0 0 0 15 0 15 0 0 15 8 0 % I
% Lys: 50 0 0 0 8 0 0 8 0 8 29 8 8 0 86 % K
% Leu: 0 0 0 36 0 15 0 0 0 58 8 22 0 0 0 % L
% Met: 0 0 0 0 0 79 0 15 0 0 0 15 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 8 0 29 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 36 0 0 0 15 0 0 0 0 22 8 % Q
% Arg: 15 0 0 0 50 0 0 0 0 0 8 0 0 0 0 % R
% Ser: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % S
% Thr: 22 0 15 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 8 8 0 0 0 0 8 0 0 0 58 72 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 43 43 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _