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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK2 All Species: 44.85
Human Site: S268 Identified Species: 70.48
UniProt: P16519 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16519 NP_002585.2 638 70565 S268 L I D I Y S A S W G P T D N G
Chimpanzee Pan troglodytes XP_001138346 638 70608 S268 L I D I Y S A S W G P T D N G
Rhesus Macaque Macaca mulatta XP_001087532 638 70521 S268 L I D I Y S A S W G P T D N G
Dog Lupus familis XP_542880 638 70588 S268 L I D I Y S A S W G P T D N G
Cat Felis silvestris
Mouse Mus musculus P21661 637 70767 S267 L I D I Y S A S W G P T D N G
Rat Rattus norvegicus P28841 637 70735 S267 L I D I Y S A S W G P T D N G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515414 639 70732 S269 V I D I Y S A S W G P T D N G
Chicken Gallus gallus XP_419332 644 71073 S274 V I D I Y S A S W G P T D N G
Frog Xenopus laevis P29119 783 86425 W252 I H I Y S A S W G P E D D G K
Zebra Danio Brachydanio rerio NP_001135738 646 71761 S274 V I D I Y S A S W G P T D D G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 W473 I D I Y S A S W G P D D D G K
Honey Bee Apis mellifera XP_392366 723 79680 S365 L I D I Y S A S W G P T D D G
Nematode Worm Caenorhab. elegans P51559 943 103128 W301 I D I Y S A S W G P E D D G K
Sea Urchin Strong. purpuratus XP_784245 750 83488 S280 E V D I Y S A S W G P Q D N G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 W273 N D I Y S C S W G P A D D G R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.4 N.A. 96.7 96.2 N.A. 92.9 88.3 39.4 82 N.A. 23.5 56 31.7 54.2
Protein Similarity: 100 99.8 100 99 N.A. 98.5 98.4 N.A. 97 93 52.4 88.6 N.A. 34.4 65.5 42.8 64.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 6.6 86.6 N.A. 6.6 93.3 6.6 80
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 26.6 100 N.A. 26.6 100 26.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 20 74 0 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 74 0 0 0 0 0 0 0 7 27 100 14 0 % D
% Glu: 7 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 27 74 0 0 0 27 74 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 20 67 27 74 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 20 % K
% Leu: 47 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 0 0 0 60 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 27 74 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % R
% Ser: 0 0 0 0 27 74 27 74 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 67 0 0 0 % T
% Val: 20 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 27 74 0 0 0 0 0 0 % W
% Tyr: 0 0 0 27 74 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _