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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK2 All Species: 36.67
Human Site: S472 Identified Species: 57.62
UniProt: P16519 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16519 NP_002585.2 638 70565 S472 R F H C V G G S V Q D P E K I
Chimpanzee Pan troglodytes XP_001138346 638 70608 S472 R F H C V G G S V Q D P E K I
Rhesus Macaque Macaca mulatta XP_001087532 638 70521 S472 R F H C V G G S V Q D P E K I
Dog Lupus familis XP_542880 638 70588 S472 R F H C V G G S V Q D P E K I
Cat Felis silvestris
Mouse Mus musculus P21661 637 70767 S471 R F H C V G G S V Q N P E K I
Rat Rattus norvegicus P28841 637 70735 S471 R F H C V G G S V Q N P E K I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515414 639 70732 S473 R F H C V G G S V Q E P E K I
Chicken Gallus gallus XP_419332 644 71073 S478 R F H C V G G S I Q E P E K I
Frog Xenopus laevis P29119 783 86425 I450 G P Q R K Y V I D I L S E P K
Zebra Danio Brachydanio rerio NP_001135738 646 71761 S478 R F H C V A G S M Q D I H K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 R668 K A V P E Q Q R C E I N A P H
Honey Bee Apis mellifera XP_392366 723 79680 K555 G A M V A L A K K W K T V P P
Nematode Worm Caenorhab. elegans P51559 943 103128 L504 I C T Y E Y R L A N P N P R P
Sea Urchin Strong. purpuratus XP_784245 750 83488 K485 R F H C T G A K W N G S S T V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 T472 Q T W F Y L P T L Y V S Q S T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.4 N.A. 96.7 96.2 N.A. 92.9 88.3 39.4 82 N.A. 23.5 56 31.7 54.2
Protein Similarity: 100 99.8 100 99 N.A. 98.5 98.4 N.A. 97 93 52.4 88.6 N.A. 34.4 65.5 42.8 64.9
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 93.3 86.6 6.6 73.3 N.A. 0 0 0 33.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 6.6 80 N.A. 13.3 0 6.6 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 0 7 7 14 0 7 0 0 0 7 0 0 % A
% Cys: 0 7 0 67 0 0 0 0 7 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 34 0 0 0 0 % D
% Glu: 0 0 0 0 14 0 0 0 0 7 14 0 60 0 0 % E
% Phe: 0 67 0 7 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 14 0 0 0 0 60 60 0 0 0 7 0 0 0 0 % G
% His: 0 0 67 0 0 0 0 0 0 0 0 0 7 0 7 % H
% Ile: 7 0 0 0 0 0 0 7 7 7 7 7 0 0 60 % I
% Lys: 7 0 0 0 7 0 0 14 7 0 7 0 0 60 7 % K
% Leu: 0 0 0 0 0 14 0 7 7 0 7 0 0 0 0 % L
% Met: 0 0 7 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 14 14 14 0 0 0 % N
% Pro: 0 7 0 7 0 0 7 0 0 0 7 54 7 20 14 % P
% Gln: 7 0 7 0 0 7 7 0 0 60 0 0 7 0 0 % Q
% Arg: 67 0 0 7 0 0 7 7 0 0 0 0 0 7 0 % R
% Ser: 0 0 0 0 0 0 0 60 0 0 0 20 7 7 0 % S
% Thr: 0 7 7 0 7 0 0 7 0 0 0 7 0 7 7 % T
% Val: 0 0 7 7 60 0 7 0 47 0 7 0 7 0 7 % V
% Trp: 0 0 7 0 0 0 0 0 7 7 0 0 0 0 0 % W
% Tyr: 0 0 0 7 7 14 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _