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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK2 All Species: 35.45
Human Site: S630 Identified Species: 55.71
UniProt: P16519 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16519 NP_002585.2 638 70565 S630 L D E A V E R S L K S I L N K
Chimpanzee Pan troglodytes XP_001138346 638 70608 S630 L D E A V E R S L K S I L N K
Rhesus Macaque Macaca mulatta XP_001087532 638 70521 S630 L D E A V E R S L K S I L S K
Dog Lupus familis XP_542880 638 70588 S630 L D E A V E R S L K S I L R K
Cat Felis silvestris
Mouse Mus musculus P21661 637 70767 S629 L D E A V E R S L Q S I L R K
Rat Rattus norvegicus P28841 637 70735 S629 L D E A V E R S L Q S I L R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515414 639 70732 S631 L D E A V E R S L K S I L S K
Chicken Gallus gallus XP_419332 644 71073 S636 L D E A V E R S L K S I L S K
Frog Xenopus laevis P29119 783 86425 N630 I H Y T L D N N I E P L L V N
Zebra Danio Brachydanio rerio NP_001135738 646 71761 S637 L D E A V E R S L K S L L S K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 K980 G E K S Y D E K S R K V V G E
Honey Bee Apis mellifera XP_392366 723 79680 A715 K L A I V K K A H E E R S S A
Nematode Worm Caenorhab. elegans P51559 943 103128 E933 T D D E D D D E D E V F V N P
Sea Urchin Strong. purpuratus XP_784245 750 83488 A654 E E E E V D Q A M K E A M M K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 D806 K L Q E L Q P D V P P S S G R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.4 N.A. 96.7 96.2 N.A. 92.9 88.3 39.4 82 N.A. 23.5 56 31.7 54.2
Protein Similarity: 100 99.8 100 99 N.A. 98.5 98.4 N.A. 97 93 52.4 88.6 N.A. 34.4 65.5 42.8 64.9
P-Site Identity: 100 100 93.3 93.3 N.A. 86.6 86.6 N.A. 93.3 93.3 6.6 86.6 N.A. 0 6.6 13.3 26.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 100 100 53.3 100 N.A. 53.3 40 40 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 60 0 0 0 14 0 0 0 7 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 67 7 0 7 27 7 7 7 0 0 0 0 0 0 % D
% Glu: 7 14 67 20 0 60 7 7 0 20 14 0 0 0 7 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 7 0 0 0 0 0 0 0 0 0 0 0 0 14 0 % G
% His: 0 7 0 0 0 0 0 0 7 0 0 0 0 0 0 % H
% Ile: 7 0 0 7 0 0 0 0 7 0 0 54 0 0 0 % I
% Lys: 14 0 7 0 0 7 7 7 0 54 7 0 0 0 67 % K
% Leu: 60 14 0 0 14 0 0 0 60 0 0 14 67 0 0 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % M
% Asn: 0 0 0 0 0 0 7 7 0 0 0 0 0 20 7 % N
% Pro: 0 0 0 0 0 0 7 0 0 7 14 0 0 0 7 % P
% Gln: 0 0 7 0 0 7 7 0 0 14 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 60 0 0 7 0 7 0 20 7 % R
% Ser: 0 0 0 7 0 0 0 60 7 0 60 7 14 34 0 % S
% Thr: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 74 0 0 0 7 0 7 7 14 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _