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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK2 All Species: 36.36
Human Site: T461 Identified Species: 57.14
UniProt: P16519 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16519 NP_002585.2 638 70565 T461 K M A K D W K T V P E R F H C
Chimpanzee Pan troglodytes XP_001138346 638 70608 T461 K M A K D W K T V P E R F H C
Rhesus Macaque Macaca mulatta XP_001087532 638 70521 T461 K M A K D W K T V P E R F H C
Dog Lupus familis XP_542880 638 70588 T461 K M A K D W K T V P E R F H C
Cat Felis silvestris
Mouse Mus musculus P21661 637 70767 T460 K M A K D W K T V P E R F H C
Rat Rattus norvegicus P28841 637 70735 T460 K M A K D W K T V P E R F H C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515414 639 70732 T462 K M A K D W K T V P E R F H C
Chicken Gallus gallus XP_419332 644 71073 T467 K M A K D W K T V P E R F H C
Frog Xenopus laevis P29119 783 86425 W439 M V A M A K T W V T V G P Q R
Zebra Danio Brachydanio rerio NP_001135738 646 71761 T467 K L A R D W K T V P E R F H C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 A657 A A E M V R V A R N W K A V P
Honey Bee Apis mellifera XP_392366 723 79680 V544 N H L F G Y G V L D A G A M V
Nematode Worm Caenorhab. elegans P51559 943 103128 P493 A K T W K T V P E Q H I C T Y
Sea Urchin Strong. purpuratus XP_784245 750 83488 I474 K L A E K W D I A P E R F H C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 N461 E M S K T W E N V N A Q T W F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.4 N.A. 96.7 96.2 N.A. 92.9 88.3 39.4 82 N.A. 23.5 56 31.7 54.2
Protein Similarity: 100 99.8 100 99 N.A. 98.5 98.4 N.A. 97 93 52.4 88.6 N.A. 34.4 65.5 42.8 64.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 13.3 86.6 N.A. 0 0 0 60
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 20 100 N.A. 6.6 13.3 0 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 74 0 7 0 0 7 7 0 14 0 14 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 67 % C
% Asp: 0 0 0 0 60 0 7 0 0 7 0 0 0 0 0 % D
% Glu: 7 0 7 7 0 0 7 0 7 0 67 0 0 0 0 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 0 67 0 7 % F
% Gly: 0 0 0 0 7 0 7 0 0 0 0 14 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 7 0 0 67 0 % H
% Ile: 0 0 0 0 0 0 0 7 0 0 0 7 0 0 0 % I
% Lys: 67 7 0 60 14 7 60 0 0 0 0 7 0 0 0 % K
% Leu: 0 14 7 0 0 0 0 0 7 0 0 0 0 0 0 % L
% Met: 7 60 0 14 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 7 0 0 0 0 0 0 7 0 14 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 7 0 67 0 0 7 0 7 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 0 7 0 7 0 % Q
% Arg: 0 0 0 7 0 7 0 0 7 0 0 67 0 0 7 % R
% Ser: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 7 0 7 7 7 60 0 7 0 0 7 7 0 % T
% Val: 0 7 0 0 7 0 14 7 74 0 7 0 0 7 7 % V
% Trp: 0 0 0 7 0 74 0 7 0 0 7 0 0 7 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _