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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK2
All Species:
47.58
Human Site:
Y265
Identified Species:
74.76
UniProt:
P16519
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16519
NP_002585.2
638
70565
Y265
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Chimpanzee
Pan troglodytes
XP_001138346
638
70608
Y265
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Rhesus Macaque
Macaca mulatta
XP_001087532
638
70521
Y265
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Dog
Lupus familis
XP_542880
638
70588
Y265
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Cat
Felis silvestris
Mouse
Mus musculus
P21661
637
70767
Y264
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Rat
Rattus norvegicus
P28841
637
70735
Y264
M
P
Q
L
I
D
I
Y
S
A
S
W
G
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515414
639
70732
Y266
M
P
Q
V
I
D
I
Y
S
A
S
W
G
P
T
Chicken
Gallus gallus
XP_419332
644
71073
Y271
M
P
Q
V
I
D
I
Y
S
A
S
W
G
P
T
Frog
Xenopus laevis
P29119
783
86425
S249
P
N
H
I
H
I
Y
S
A
S
W
G
P
E
D
Zebra Danio
Brachydanio rerio
NP_001135738
646
71761
Y271
M
P
Q
V
I
D
I
Y
S
A
S
W
G
P
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26016
1269
138609
S470
P
Q
H
I
D
I
Y
S
A
S
W
G
P
D
D
Honey Bee
Apis mellifera
XP_392366
723
79680
Y362
E
P
D
L
I
D
I
Y
S
A
S
W
G
P
T
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S298
Q
D
H
I
D
I
Y
S
A
S
W
G
P
E
D
Sea Urchin
Strong. purpuratus
XP_784245
750
83488
Y277
L
P
Q
E
V
D
I
Y
S
A
S
W
G
P
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
S270
L
D
V
N
D
I
Y
S
C
S
W
G
P
A
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
98.4
N.A.
96.7
96.2
N.A.
92.9
88.3
39.4
82
N.A.
23.5
56
31.7
54.2
Protein Similarity:
100
99.8
100
99
N.A.
98.5
98.4
N.A.
97
93
52.4
88.6
N.A.
34.4
65.5
42.8
64.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
0
93.3
N.A.
0
86.6
0
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
20
100
N.A.
20
86.6
20
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
20
74
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% C
% Asp:
0
14
7
0
20
74
0
0
0
0
0
0
0
7
27
% D
% Glu:
7
0
0
7
0
0
0
0
0
0
0
0
0
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
27
74
0
0
% G
% His:
0
0
20
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
20
67
27
74
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
14
0
0
47
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
60
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
14
74
0
0
0
0
0
0
0
0
0
0
27
74
0
% P
% Gln:
7
7
67
0
0
0
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
27
74
27
74
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
67
% T
% Val:
0
0
7
20
7
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
27
74
0
0
0
% W
% Tyr:
0
0
0
0
0
0
27
74
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _