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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK2
All Species:
36.97
Human Site:
Y373
Identified Species:
58.1
UniProt:
P16519
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16519
NP_002585.2
638
70565
Y373
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Chimpanzee
Pan troglodytes
XP_001138346
638
70608
Y373
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Rhesus Macaque
Macaca mulatta
XP_001087532
638
70521
Y373
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Dog
Lupus familis
XP_542880
638
70588
Y373
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Cat
Felis silvestris
Mouse
Mus musculus
P21661
637
70767
Y372
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Rat
Rattus norvegicus
P28841
637
70735
Y372
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515414
639
70732
Y374
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Chicken
Gallus gallus
XP_419332
644
71073
Y379
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Frog
Xenopus laevis
P29119
783
86425
K357
V
T
T
D
L
R
Q
K
C
T
D
S
H
T
G
Zebra Danio
Brachydanio rerio
NP_001135738
646
71761
Y379
G
V
A
T
T
D
L
Y
G
N
C
T
L
R
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P26016
1269
138609
S578
V
T
T
D
L
H
H
S
C
T
V
S
H
T
G
Honey Bee
Apis mellifera
XP_392366
723
79680
G470
V
A
T
T
D
L
Y
G
K
C
T
T
T
H
S
Nematode Worm
Caenorhab. elegans
P51559
943
103128
G406
V
T
V
D
V
P
G
G
C
T
D
K
H
T
G
Sea Urchin
Strong. purpuratus
XP_784245
750
83488
L385
A
G
V
A
T
T
D
L
Y
G
N
C
T
L
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
S378
S
D
I
N
G
R
C
S
N
S
H
G
G
T
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
98.4
N.A.
96.7
96.2
N.A.
92.9
88.3
39.4
82
N.A.
23.5
56
31.7
54.2
Protein Similarity:
100
99.8
100
99
N.A.
98.5
98.4
N.A.
97
93
52.4
88.6
N.A.
34.4
65.5
42.8
64.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
0
100
N.A.
0
13.3
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
6.6
100
N.A.
6.6
13.3
0
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
60
7
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
7
0
20
7
60
7
0
0
0
% C
% Asp:
0
7
0
20
7
60
7
0
0
0
14
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
60
7
0
0
7
0
7
14
60
7
0
7
7
0
20
% G
% His:
0
0
0
0
0
7
7
0
0
0
7
0
20
7
60
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
7
7
0
0
7
0
0
0
% K
% Leu:
0
0
0
0
14
7
60
7
0
0
0
0
60
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
7
60
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
14
0
0
0
0
0
0
0
60
0
% R
% Ser:
7
0
0
0
0
0
0
14
0
7
0
14
0
0
20
% S
% Thr:
0
20
20
67
67
7
0
0
0
20
7
67
14
27
0
% T
% Val:
27
60
14
0
7
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
60
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _