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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCSK2 All Species: 34.85
Human Site: Y599 Identified Species: 54.76
UniProt: P16519 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P16519 NP_002585.2 638 70565 Y599 H G T Q S A P Y I D Q V V R D
Chimpanzee Pan troglodytes XP_001138346 638 70608 Y599 H G T Q S A P Y I D Q V V R D
Rhesus Macaque Macaca mulatta XP_001087532 638 70521 Y599 H G T Q S A P Y I D Q V V R D
Dog Lupus familis XP_542880 638 70588 Y599 H G T Q S A P Y I D Q V V R D
Cat Felis silvestris
Mouse Mus musculus P21661 637 70767 Y598 H G T Q S A P Y I D Q V V R D
Rat Rattus norvegicus P28841 637 70735 Y598 H G T Q S A P Y I D Q V V R D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515414 639 70732 Y600 H G T Q S A P Y I D Q V V K D
Chicken Gallus gallus XP_419332 644 71073 Y605 H G T Q S A P Y I D Q I V K D
Frog Xenopus laevis P29119 783 86425 S577 G T A S E G L S R K F D G D G
Zebra Danio Brachydanio rerio NP_001135738 646 71761 P605 L H G T Q S A P Y I D Q V V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P26016 1269 138609 G795 Y G T T Q S I G P N D P I S V
Honey Bee Apis mellifera XP_392366 723 79680 I682 Q T P Q H G W I R E W T L M L
Nematode Worm Caenorhab. elegans P51559 943 103128 Q631 Y G T A D P A Q S G D P V Y S
Sea Urchin Strong. purpuratus XP_784245 750 83488 Y612 H G T Q S A S Y I E E A N A R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13134 814 89984 K599 G E S I D S S K T E T F V F G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99.6 98.4 N.A. 96.7 96.2 N.A. 92.9 88.3 39.4 82 N.A. 23.5 56 31.7 54.2
Protein Similarity: 100 99.8 100 99 N.A. 98.5 98.4 N.A. 97 93 52.4 88.6 N.A. 34.4 65.5 42.8 64.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 86.6 0 6.6 N.A. 13.3 6.6 20 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 0 13.3 N.A. 40 20 26.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 0 60 14 0 0 0 0 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 14 0 0 0 0 54 20 7 0 7 54 % D
% Glu: 0 7 0 0 7 0 0 0 0 20 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 7 7 0 7 0 % F
% Gly: 14 74 7 0 0 14 0 7 0 7 0 0 7 0 14 % G
% His: 60 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 0 7 7 60 7 0 7 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 7 0 7 0 0 0 14 0 % K
% Leu: 7 0 0 0 0 0 7 0 0 0 0 0 7 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % N
% Pro: 0 0 7 0 0 7 54 7 7 0 0 14 0 0 0 % P
% Gln: 7 0 0 67 14 0 0 7 0 0 54 7 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 14 0 0 0 0 40 14 % R
% Ser: 0 0 7 7 60 20 14 7 7 0 0 0 0 7 7 % S
% Thr: 0 14 74 14 0 0 0 0 7 0 7 7 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 47 74 7 7 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 7 0 0 0 0 % W
% Tyr: 14 0 0 0 0 0 0 60 7 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _