KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
19.09
Human Site:
S925
Identified Species:
38.18
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
S925
K
Y
W
E
K
N
Q
S
I
A
I
E
L
S
D
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
S925
K
Y
W
E
K
N
Q
S
I
A
I
E
L
S
D
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
S925
K
Y
W
E
K
N
Q
S
I
A
I
E
L
S
D
Dog
Lupus familis
XP_546812
1252
146274
K918
D
T
K
E
N
N
M
K
Y
W
E
K
N
Q
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
S925
K
Y
W
E
R
N
Q
S
I
A
I
E
L
S
D
Rat
Rattus norvegicus
P24135
1265
147716
S925
K
Y
W
E
R
N
Q
S
I
A
I
E
L
S
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
S657
Q
S
I
A
I
E
L
S
D
L
V
V
Y
C
K
Chicken
Gallus gallus
Q2VRL0
637
72514
K303
K
I
L
V
K
N
K
K
C
G
T
I
E
E
T
Frog
Xenopus laevis
Q32NH8
758
87399
D424
P
V
R
L
P
S
P
D
E
L
R
G
K
I
L
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
K450
L
P
S
P
E
E
L
K
G
R
I
L
L
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
L800
I
M
G
A
V
V
E
L
R
V
G
G
R
P
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
I606
V
P
F
S
E
E
R
I
P
G
K
Y
F
E
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
13.3
N.A.
93.3
93.3
N.A.
6.6
20
0
13.3
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
100
20
N.A.
100
100
N.A.
20
26.6
6.6
20
N.A.
N.A.
13.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
17
0
0
0
0
0
42
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
9
0
% C
% Asp:
9
0
0
0
0
0
0
9
9
0
0
0
0
0
50
% D
% Glu:
0
0
0
50
17
25
9
0
9
0
9
42
9
17
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
9
0
0
% F
% Gly:
0
0
9
0
0
0
0
0
9
17
9
17
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
9
9
0
9
0
0
9
42
0
50
9
0
9
0
% I
% Lys:
50
0
9
0
34
0
9
25
0
0
9
9
9
9
9
% K
% Leu:
9
0
9
9
0
0
17
9
0
17
0
9
50
0
9
% L
% Met:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
0
9
59
0
0
0
0
0
0
9
0
0
% N
% Pro:
9
17
0
9
9
0
9
0
9
0
0
0
0
9
0
% P
% Gln:
9
0
0
0
0
0
42
0
0
0
0
0
0
9
0
% Q
% Arg:
0
0
9
0
17
0
9
0
9
9
9
0
9
0
0
% R
% Ser:
0
9
9
9
0
9
0
50
0
0
0
0
0
42
9
% S
% Thr:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
9
% T
% Val:
9
9
0
9
9
9
0
0
0
9
9
9
0
0
0
% V
% Trp:
0
0
42
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
42
0
0
0
0
0
0
9
0
0
9
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _