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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCG2
All Species:
22.73
Human Site:
Y680
Identified Species:
45.45
UniProt:
P16885
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P16885
NP_002652.2
1265
147870
Y680
K
R
E
G
S
D
S
Y
A
I
T
F
R
A
R
Chimpanzee
Pan troglodytes
XP_001147944
1265
147906
Y680
K
R
E
G
S
D
S
Y
A
I
T
F
R
A
R
Rhesus Macaque
Macaca mulatta
XP_001111677
1265
147898
Y680
K
R
E
G
S
D
S
Y
A
I
T
F
R
A
R
Dog
Lupus familis
XP_546812
1252
146274
Y680
R
R
E
G
T
D
S
Y
A
I
T
F
R
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIH5
1265
147573
Y680
K
R
E
G
T
N
S
Y
A
I
T
F
R
A
R
Rat
Rattus norvegicus
P24135
1265
147716
Y680
K
R
E
G
T
D
S
Y
A
I
T
F
R
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508105
991
115582
R427
C
R
I
N
Q
D
G
R
H
F
V
L
G
T
S
Chicken
Gallus gallus
Q2VRL0
637
72514
N73
Y
R
A
I
V
H
R
N
E
F
H
E
I
F
C
Frog
Xenopus laevis
Q32NH8
758
87399
E194
S
G
T
L
E
G
E
E
F
V
L
F
Y
K
A
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
I220
G
R
L
D
H
V
E
I
E
E
F
C
R
E
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624101
1134
132613
Q570
R
S
H
P
L
R
S
Q
E
F
L
I
T
L
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784329
940
107748
Q376
L
F
T
I
G
S
A
Q
F
E
S
L
A
E
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98
94.4
N.A.
94.1
94.7
N.A.
62.7
20.7
22.1
21.2
N.A.
N.A.
40.9
N.A.
32.9
Protein Similarity:
100
99.9
99.2
97
N.A.
97.1
97.3
N.A.
67.8
33.2
37.5
34.9
N.A.
N.A.
59.1
N.A.
49
P-Site Identity:
100
100
100
86.6
N.A.
86.6
93.3
N.A.
13.3
6.6
6.6
13.3
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
6.6
13.3
13.3
N.A.
N.A.
20
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
9
0
0
0
9
0
50
0
0
0
9
50
9
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% C
% Asp:
0
0
0
9
0
50
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
50
0
9
0
17
9
25
17
0
9
0
17
0
% E
% Phe:
0
9
0
0
0
0
0
0
17
25
9
59
0
9
0
% F
% Gly:
9
9
0
50
9
9
9
0
0
0
0
0
9
0
0
% G
% His:
0
0
9
0
9
9
0
0
9
0
9
0
0
0
0
% H
% Ile:
0
0
9
17
0
0
0
9
0
50
0
9
9
0
0
% I
% Lys:
42
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% K
% Leu:
9
0
9
9
9
0
0
0
0
0
17
17
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
9
0
9
0
9
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
9
0
0
17
0
0
0
0
0
0
9
% Q
% Arg:
17
75
0
0
0
9
9
9
0
0
0
0
59
0
50
% R
% Ser:
9
9
0
0
25
9
59
0
0
0
9
0
0
0
9
% S
% Thr:
0
0
17
0
25
0
0
0
0
0
50
0
9
9
0
% T
% Val:
0
0
0
0
9
9
0
0
0
9
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
50
0
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _