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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GOT1 All Species: 30
Human Site: Y124 Identified Species: 50.77
UniProt: P17174 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17174 NP_002070.1 413 46248 Y124 A D F L A R W Y N G T N N K N
Chimpanzee Pan troglodytes A5A6K8 413 46215 Y124 A D F L A R W Y N G T N N K N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_543963 413 46395 Y124 A E F L A R W Y N G T N N K D
Cat Felis silvestris
Mouse Mus musculus P05201 413 46213 Y124 A D F L G R W Y N G T D N K N
Rat Rattus norvegicus P13221 413 46410 Y124 A D F L G R W Y N G T D N K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507985 380 42638 I101 P A I K E K R I G S V Q C L G
Chicken Gallus gallus P00504 412 45917 Y123 A E F L R R W Y N G N N N T A
Frog Xenopus laevis NP_001080543 411 46052 Y122 A E F L R R W Y N G N N N T A
Zebra Danio Brachydanio rerio NP_998222 410 45964 Y121 A E F L R R W Y N G T D N T K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611086 416 46069 L121 A D F L H T Q L N R N V V Y Y
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22067 408 45475 C121 A E F L A S V C N M K T V Y V
Sea Urchin Strong. purpuratus XP_794016 614 68362 A326 C D F L S R R A N Y K I V Y V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P46644 449 48936 Y166 G E F L A K H Y H Q K T I Y I
Baker's Yeast Sacchar. cerevisiae P23542 418 46039 F123 A K F F S K F F P D K L V Y L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 92.4 N.A. 91 90.3 N.A. 76 80.1 79.9 76.5 N.A. 55.2 N.A. 54.2 39.9
Protein Similarity: 100 100 N.A. 96.6 N.A. 96.3 95.6 N.A. 84.5 89.5 89.5 88.1 N.A. 70.9 N.A. 68.2 50.6
P-Site Identity: 100 100 N.A. 86.6 N.A. 86.6 86.6 N.A. 0 66.6 66.6 66.6 N.A. 33.3 N.A. 33.3 33.3
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 6.6 73.3 73.3 80 N.A. 33.3 N.A. 40 40
Percent
Protein Identity: N.A. N.A. N.A. 45.8 46.4 N.A.
Protein Similarity: N.A. N.A. N.A. 63.4 62.6 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 79 8 0 0 36 0 0 8 0 0 0 0 0 0 15 % A
% Cys: 8 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % C
% Asp: 0 43 0 0 0 0 0 0 0 8 0 22 0 0 8 % D
% Glu: 0 43 0 0 8 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 93 8 0 0 8 8 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 15 0 0 0 8 58 0 0 0 0 8 % G
% His: 0 0 0 0 8 0 8 0 8 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 8 0 0 0 8 8 0 8 % I
% Lys: 0 8 0 8 0 22 0 0 0 0 29 0 0 36 8 % K
% Leu: 0 0 0 86 0 0 0 8 0 0 0 8 0 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 79 0 22 36 58 0 29 % N
% Pro: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 8 0 0 8 0 8 0 0 0 % Q
% Arg: 0 0 0 0 22 65 15 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 0 15 8 0 0 0 8 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 8 0 0 0 0 43 15 0 22 0 % T
% Val: 0 0 0 0 0 0 8 0 0 0 8 8 29 0 15 % V
% Trp: 0 0 0 0 0 0 58 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 65 0 8 0 0 0 36 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _