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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AKR1C4
All Species:
15.15
Human Site:
T221
Identified Species:
66.67
UniProt:
P17516
Number Species:
5
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17516
NP_001809.2
323
37095
T221
V
A
H
S
A
L
G
T
Q
R
H
K
L
W
V
Chimpanzee
Pan troglodytes
XP_001142789
323
37158
T221
V
A
H
S
A
L
G
T
Q
R
H
E
L
W
V
Rhesus Macaque
Macaca mulatta
XP_001104543
323
36869
S221
V
A
Y
S
A
L
G
S
Q
R
D
K
R
W
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P70694
323
37029
S221
V
A
Y
S
A
L
G
S
H
R
E
K
Q
W
V
Rat
Rattus norvegicus
P23457
322
37009
S221
V
S
Y
C
T
L
G
S
S
R
D
K
T
W
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q568L5
324
36800
D216
Y
S
P
L
G
S
P
D
R
A
W
K
H
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
85.1
N.A.
N.A.
75.8
69
N.A.
N.A.
N.A.
N.A.
45.6
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.7
91.9
N.A.
N.A.
88.2
83.2
N.A.
N.A.
N.A.
N.A.
66.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
73.3
N.A.
N.A.
66.6
46.6
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
N.A.
N.A.
80
66.6
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
67
0
0
67
0
0
0
0
17
0
0
0
0
0
% A
% Cys:
0
0
0
17
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
17
0
0
34
0
0
0
17
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
17
17
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
17
0
84
0
0
0
0
0
0
0
0
% G
% His:
0
0
34
0
0
0
0
0
17
0
34
0
17
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
84
0
0
0
% K
% Leu:
0
0
0
17
0
84
0
0
0
0
0
0
34
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
17
0
0
0
17
0
0
0
0
0
0
17
0
% P
% Gln:
0
0
0
0
0
0
0
0
50
0
0
0
17
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
17
84
0
0
17
0
0
% R
% Ser:
0
34
0
67
0
17
0
50
17
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
17
0
0
34
0
0
0
0
17
0
0
% T
% Val:
84
0
0
0
0
0
0
0
0
0
0
0
0
0
84
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
17
0
0
84
0
% W
% Tyr:
17
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _