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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN2
All Species:
20
Human Site:
Y154
Identified Species:
40
UniProt:
P17706
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17706
NP_002819.1
415
48473
Y154
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
L
Chimpanzee
Pan troglodytes
XP_512196
415
48479
Y154
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
L
Rhesus Macaque
Macaca mulatta
XP_001118328
448
50818
K200
K
K
Q
Q
L
I
F
K
N
L
L
V
G
K
T
Dog
Lupus familis
XP_547685
388
45298
V144
F
K
E
T
G
F
S
V
K
F
L
S
E
D
V
Cat
Felis silvestris
Mouse
Mus musculus
Q06180
406
47342
Y154
S
E
D
V
K
S
Y
Y
T
V
H
L
L
Q
L
Rat
Rattus norvegicus
P35233
363
42217
E119
L
N
R
T
V
E
K
E
S
V
K
C
A
Q
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508429
545
61767
Y155
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
Chicken
Gallus gallus
O13016
434
50316
Y153
S
E
D
I
K
S
Y
Y
T
V
R
Q
L
E
L
Frog
Xenopus laevis
NP_001086910
468
54192
K162
L
L
Q
L
Q
D
I
K
T
G
E
T
R
D
I
Zebra Danio
Brachydanio rerio
NP_997819
393
45640
S149
L
V
S
E
D
V
K
S
Y
Y
T
T
R
V
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W0G1
548
62086
Y172
E
L
V
R
L
E
T
Y
Q
N
F
V
R
R
W
Honey Bee
Apis mellifera
XP_392429
495
55903
S165
K
Y
I
S
K
T
E
S
S
D
Y
T
T
R
I
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
69.1
86.9
N.A.
88.6
79.7
N.A.
41.4
53
54.2
57.5
N.A.
31.9
40.2
N.A.
N.A.
Protein Similarity:
100
99.7
75.8
88.9
N.A.
92.5
84
N.A.
53.2
70
67
71.5
N.A.
46.9
55.5
N.A.
N.A.
P-Site Identity:
100
100
0
0
N.A.
100
13.3
N.A.
73.3
73.3
6.6
6.6
N.A.
6.6
6.6
N.A.
N.A.
P-Site Similarity:
100
100
33.3
20
N.A.
100
20
N.A.
86.6
86.6
26.6
6.6
N.A.
20
40
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
0
0
42
0
9
9
0
0
0
9
0
0
0
17
0
% D
% Glu:
9
42
9
9
0
17
9
9
0
0
9
0
9
17
0
% E
% Phe:
9
0
0
0
0
9
9
0
0
9
9
0
0
0
0
% F
% Gly:
0
0
0
0
9
0
0
0
0
9
0
0
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
25
0
0
0
0
% H
% Ile:
0
0
9
17
0
9
9
0
0
0
0
0
0
0
17
% I
% Lys:
17
17
0
0
50
0
17
17
9
0
9
0
0
9
0
% K
% Leu:
25
17
0
9
17
0
0
0
0
9
17
25
42
0
50
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
9
9
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
17
9
9
0
0
0
9
0
0
17
0
34
0
% Q
% Arg:
0
0
9
9
0
0
0
0
0
0
17
0
25
17
0
% R
% Ser:
42
0
9
9
0
42
9
17
17
0
0
9
0
0
0
% S
% Thr:
0
0
0
17
0
9
9
0
50
0
9
25
9
0
9
% T
% Val:
0
9
9
25
9
9
0
9
0
50
0
17
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
0
9
0
0
0
0
42
50
9
9
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _