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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ENG All Species: 2.73
Human Site: S619 Identified Species: 8.57
UniProt: P17813 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17813 NP_000109.1 658 70578 S619 Y I Y S H T R S P S K R E P V
Chimpanzee Pan troglodytes XP_001143396 613 65795 P575 I Y S H T R S P S K R E P V V
Rhesus Macaque Macaca mulatta XP_001098070 860 94576 T821 L W Y I Y S H T G E T A G R Q
Dog Lupus familis XP_851469 721 77457 P682 Y I Y S H T R P P G K R E P V
Cat Felis silvestris
Mouse Mus musculus Q63961 653 70018 G614 Y I Y S H T R G P S K R E P V
Rat Rattus norvegicus P26342 853 94084 K768 K E N V P S T K D S S P I P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001074356 644 70806 T605 L W Y I Y S H T R P I S K L Q
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_686315 549 60271 G511 W F I Y S H T G G T A A G Q Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 84.6 24.7 67.6 N.A. 71.4 22.5 N.A. N.A. 36 N.A. 21.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 86.6 40.1 74.4 N.A. 79.4 38.9 N.A. N.A. 50.6 N.A. 34.7 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 86.6 N.A. 93.3 13.3 N.A. N.A. 6.6 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 26.6 86.6 N.A. 93.3 20 N.A. N.A. 33.3 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 13 25 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % D
% Glu: 0 13 0 0 0 0 0 0 0 13 0 13 38 0 0 % E
% Phe: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 25 25 13 0 0 25 0 0 % G
% His: 0 0 0 13 38 13 25 0 0 0 0 0 0 0 0 % H
% Ile: 13 38 13 25 0 0 0 0 0 0 13 0 13 0 0 % I
% Lys: 13 0 0 0 0 0 0 13 0 13 38 0 13 0 0 % K
% Leu: 25 0 0 0 0 0 0 0 0 0 0 0 0 13 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 13 0 0 25 38 13 0 13 13 50 13 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 13 38 % Q
% Arg: 0 0 0 0 0 13 38 0 13 0 13 38 0 13 0 % R
% Ser: 0 0 13 38 13 38 13 13 13 38 13 13 0 0 0 % S
% Thr: 0 0 0 0 13 38 25 25 0 13 13 0 0 0 0 % T
% Val: 0 0 0 13 0 0 0 0 0 0 0 0 0 13 50 % V
% Trp: 13 25 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 38 13 63 13 25 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _