KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKL
All Species:
18.79
Human Site:
S277
Identified Species:
34.44
UniProt:
P17858
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17858
NP_002617.3
780
85018
S277
N
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
S277
N
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
E348
N
G
K
P
I
T
S
E
D
I
K
N
L
V
V
Dog
Lupus familis
XP_544922
751
82459
T262
V
Q
R
L
G
F
D
T
R
V
T
V
L
G
H
Cat
Felis silvestris
Mouse
Mus musculus
P12382
780
85282
S277
H
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Rat
Rattus norvegicus
P30835
780
85320
S277
H
G
K
P
I
S
S
S
Y
V
K
D
L
V
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514123
751
82475
T262
V
K
R
L
G
F
D
T
R
V
T
V
L
G
H
Chicken
Gallus gallus
XP_001232621
780
85127
N277
N
G
K
P
I
S
S
N
Y
V
K
D
L
V
V
Frog
Xenopus laevis
NP_001091319
786
86623
D278
H
N
K
P
I
T
S
D
L
V
K
D
L
V
M
Zebra Danio
Brachydanio rerio
XP_698635
780
84600
N277
S
G
E
A
I
T
S
N
Y
I
K
D
L
V
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
E279
E
G
H
P
I
T
A
E
D
V
K
K
V
I
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
R270
K
G
Q
R
I
D
V
R
Q
V
K
E
E
I
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
S460
D
L
T
P
I
S
P
S
D
V
H
K
V
L
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
63.8
90.1
N.A.
94
94.2
N.A.
86.6
86.7
68.4
77.5
N.A.
55.5
N.A.
40.1
N.A.
Protein Similarity:
100
99.6
77.3
93
N.A.
97.1
97.3
N.A.
91.9
93.8
83.7
89.6
N.A.
73
N.A.
58.2
N.A.
P-Site Identity:
100
100
66.6
13.3
N.A.
93.3
93.3
N.A.
13.3
93.3
60
60
N.A.
33.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
86.6
26.6
N.A.
100
100
N.A.
26.6
100
80
93.3
N.A.
60
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
0
8
16
8
24
0
0
54
0
0
8
% D
% Glu:
8
0
8
0
0
0
0
16
0
0
0
8
8
0
8
% E
% Phe:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
70
0
0
16
0
0
0
0
0
0
0
0
16
0
% G
% His:
24
0
8
0
0
0
0
0
0
0
8
0
0
0
16
% H
% Ile:
0
0
0
0
85
0
0
0
0
16
0
0
0
16
0
% I
% Lys:
8
8
54
0
0
0
0
0
0
0
77
16
0
0
0
% K
% Leu:
0
8
0
16
0
0
0
0
8
0
0
0
77
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
31
8
0
0
0
0
0
16
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
70
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
8
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
16
8
0
0
0
8
16
0
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
47
62
39
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
31
0
16
0
0
16
0
0
0
0
% T
% Val:
16
0
0
0
0
0
8
0
0
85
0
16
16
62
62
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
47
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _