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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKL
All Species:
21.82
Human Site:
S398
Identified Species:
40
UniProt:
P17858
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P17858
NP_002617.3
780
85018
S398
Q
K
P
P
K
E
K
S
N
F
S
L
A
I
L
Chimpanzee
Pan troglodytes
XP_001150233
780
84936
S398
Q
K
P
P
K
E
K
S
N
F
S
L
A
I
L
Rhesus Macaque
Macaca mulatta
XP_001096244
851
93251
S469
V
R
P
P
V
S
K
S
G
S
H
T
V
A
V
Dog
Lupus familis
XP_544922
751
82459
N386
G
A
P
A
A
G
M
N
A
A
V
R
S
A
V
Cat
Felis silvestris
Mouse
Mus musculus
P12382
780
85282
S398
Q
K
V
S
K
E
K
S
N
F
S
L
A
I
L
Rat
Rattus norvegicus
P30835
780
85320
S398
Q
K
V
S
K
E
K
S
N
F
S
L
A
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514123
751
82475
N386
G
A
P
A
A
G
M
N
A
A
V
R
S
A
V
Chicken
Gallus gallus
XP_001232621
780
85127
S398
Q
K
P
A
Q
E
K
S
P
F
S
L
A
I
L
Frog
Xenopus laevis
NP_001091319
786
86623
P399
K
K
N
V
S
E
L
P
K
S
N
F
N
V
A
Zebra Danio
Brachydanio rerio
XP_698635
780
84600
S398
Q
K
S
A
A
V
Q
S
E
H
S
I
A
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52034
788
86630
F400
L
K
P
P
K
E
N
F
D
A
D
G
K
G
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q27483
756
83282
S392
Q
T
Y
L
N
F
V
S
I
P
L
S
T
T
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P16862
959
104599
K585
E
P
K
L
P
K
D
K
R
L
K
I
A
I
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
63.8
90.1
N.A.
94
94.2
N.A.
86.6
86.7
68.4
77.5
N.A.
55.5
N.A.
40.1
N.A.
Protein Similarity:
100
99.6
77.3
93
N.A.
97.1
97.3
N.A.
91.9
93.8
83.7
89.6
N.A.
73
N.A.
58.2
N.A.
P-Site Identity:
100
100
26.6
6.6
N.A.
86.6
86.6
N.A.
6.6
80
13.3
46.6
N.A.
33.3
N.A.
13.3
N.A.
P-Site Similarity:
100
100
40
26.6
N.A.
86.6
86.6
N.A.
26.6
86.6
33.3
60
N.A.
46.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
36.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
31
24
0
0
0
16
24
0
0
54
24
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
8
0
8
0
0
0
0
% D
% Glu:
8
0
0
0
0
54
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
8
0
39
0
8
0
0
0
% F
% Gly:
16
0
0
0
0
16
0
0
8
0
0
8
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
8
0
0
16
0
54
8
% I
% Lys:
8
62
8
0
39
8
47
8
8
0
8
0
8
0
0
% K
% Leu:
8
0
0
16
0
0
8
0
0
8
8
39
0
0
47
% L
% Met:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
8
0
8
16
31
0
8
0
8
0
0
% N
% Pro:
0
8
54
31
8
0
0
8
8
8
0
0
0
0
0
% P
% Gln:
54
0
0
0
8
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
8
0
0
16
0
0
0
% R
% Ser:
0
0
8
16
8
8
0
62
0
16
47
8
16
0
0
% S
% Thr:
0
8
0
0
0
0
0
0
0
0
0
8
8
8
0
% T
% Val:
8
0
16
8
8
8
8
0
0
0
16
0
8
8
31
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _