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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSMC3 All Species: 17.27
Human Site: T12 Identified Species: 25.33
UniProt: P17980 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17980 NP_002795.2 439 49204 T12 P N I E S P V T R Q E K M A T
Chimpanzee Pan troglodytes XP_508413 555 61671 T128 P N L E S P V T R Q E K M A T
Rhesus Macaque Macaca mulatta XP_001106497 439 49185 T12 P N L E S P V T R Q E K M A T
Dog Lupus familis XP_533187 402 44931 I13 D E A E Q D G I G E E V L K M
Cat Felis silvestris
Mouse Mus musculus O88685 442 49474 T15 P T P E S P V T R Q E K M A T
Rat Rattus norvegicus Q63569 439 49142 T12 P T P E S P V T R Q E K M A T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90732 440 49185 K21 G K K D D K D K K K K Y E P P
Frog Xenopus laevis O42586 404 45258 L12 E I I Q R T R L L D S E I K I
Zebra Danio Brachydanio rerio NP_001002064 404 45291 L12 E I V Q R T R L L D S E I K I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P48601 439 49305 K14 A Q G G A G E K K D D K D K K
Honey Bee Apis mellifera XP_392722 428 47609 E11 L E D K S L W E D G E E A L G
Nematode Worm Caenorhab. elegans O16368 443 49704 R11 Q Q S G F G G R G N D R G A G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002330164 423 47370 F11 P M A E D S S F E D D Q L A S
Maize Zea mays NP_001142386 430 47792 A11 S G A P A P A A A M A V D D A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O04019 423 47019 F11 A M A E D T S F E G D Q L A S
Baker's Yeast Sacchar. cerevisiae P33297 434 48237 T11 L E E L D A Q T L P G D D E L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 78.9 99.7 91.5 N.A. 97.9 99.3 N.A. N.A. 40 90.8 90.4 N.A. 40 83.8 39.5 N.A.
Protein Similarity: 100 79 100 91.5 N.A. 98.6 99.5 N.A. N.A. 60.9 91.5 91.1 N.A. 60.5 91.1 59.5 N.A.
P-Site Identity: 100 93.3 93.3 13.3 N.A. 86.6 86.6 N.A. N.A. 0 6.6 0 N.A. 6.6 13.3 6.6 N.A.
P-Site Similarity: 100 100 100 26.6 N.A. 86.6 86.6 N.A. N.A. 26.6 26.6 26.6 N.A. 26.6 26.6 20 N.A.
Percent
Protein Identity: 74 75.6 N.A. 73.1 67.6 N.A.
Protein Similarity: 87 88.6 N.A. 85.4 84 N.A.
P-Site Identity: 20 6.6 N.A. 13.3 6.6 N.A.
P-Site Similarity: 46.6 13.3 N.A. 40 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 0 25 0 13 7 7 7 7 0 7 0 7 50 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 7 7 25 7 7 0 7 25 25 7 19 7 0 % D
% Glu: 13 19 7 50 0 0 7 7 13 7 44 19 7 7 0 % E
% Phe: 0 0 0 0 7 0 0 13 0 0 0 0 0 0 0 % F
% Gly: 7 7 7 13 0 13 13 0 13 13 7 0 7 0 13 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 13 13 0 0 0 0 7 0 0 0 0 13 0 13 % I
% Lys: 0 7 7 7 0 7 0 13 13 7 7 38 0 25 7 % K
% Leu: 13 0 13 7 0 7 0 13 19 0 0 0 19 7 7 % L
% Met: 0 13 0 0 0 0 0 0 0 7 0 0 32 0 7 % M
% Asn: 0 19 0 0 0 0 0 0 0 7 0 0 0 0 0 % N
% Pro: 38 0 13 7 0 38 0 0 0 7 0 0 0 7 7 % P
% Gln: 7 13 0 13 7 0 7 0 0 32 0 13 0 0 0 % Q
% Arg: 0 0 0 0 13 0 13 7 32 0 0 7 0 0 0 % R
% Ser: 7 0 7 0 38 7 13 0 0 0 13 0 0 0 13 % S
% Thr: 0 13 0 0 0 19 0 38 0 0 0 0 0 0 32 % T
% Val: 0 0 7 0 0 0 32 0 0 0 0 13 0 0 0 % V
% Trp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _