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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN1
All Species:
5.45
Human Site:
S378
Identified Species:
12
UniProt:
P18031
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18031
NP_002818.1
435
49967
S378
R
S
R
V
V
G
G
S
L
R
G
A
Q
A
A
Chimpanzee
Pan troglodytes
XP_512196
415
48479
R357
R
K
R
I
R
E
D
R
K
A
T
T
A
Q
K
Rhesus Macaque
Macaca mulatta
XP_001096290
435
49928
S378
R
S
R
V
V
G
G
S
L
R
G
A
Q
A
A
Dog
Lupus familis
XP_534455
424
48717
P354
I
K
E
E
T
R
T
P
L
N
V
P
C
S
V
Cat
Felis silvestris
Mouse
Mus musculus
P35821
432
49575
G375
E
V
R
R
R
M
V
G
G
G
L
Q
S
A
Q
Rat
Rattus norvegicus
P20417
432
49656
M373
D
T
E
V
R
K
R
M
V
G
G
G
L
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508429
545
61767
R379
Q
D
T
G
V
R
R
R
T
V
G
E
H
Q
R
Chicken
Gallus gallus
O13016
434
50316
R377
Q
D
T
E
I
R
R
R
T
V
G
E
N
L
H
Frog
Xenopus laevis
NP_001086085
428
49306
T370
A
E
S
A
R
P
D
T
E
M
R
R
R
A
V
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W0G1
548
62086
L396
D
S
R
P
L
P
P
L
P
V
R
A
F
N
D
Honey Bee
Apis mellifera
XP_392429
495
55903
L366
T
G
P
P
D
K
P
L
P
R
E
P
S
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
54
97.6
88.5
N.A.
82.9
84.3
N.A.
58.1
78.1
70.8
N.A.
N.A.
34.1
40
N.A.
N.A.
Protein Similarity:
100
69.8
99
92.8
N.A.
90.5
90.8
N.A.
66.2
86.9
82.3
N.A.
N.A.
49.4
57.1
N.A.
N.A.
P-Site Identity:
100
13.3
100
6.6
N.A.
13.3
13.3
N.A.
13.3
6.6
6.6
N.A.
N.A.
20
6.6
N.A.
N.A.
P-Site Similarity:
100
20
100
13.3
N.A.
13.3
33.3
N.A.
20
20
20
N.A.
N.A.
26.6
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
0
0
0
0
0
10
0
28
10
37
19
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
19
19
0
0
10
0
19
0
0
0
0
0
0
0
10
% D
% Glu:
10
10
19
19
0
10
0
0
10
0
10
19
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
10
0
10
0
19
19
10
10
19
46
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
10
% H
% Ile:
10
0
0
10
10
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
0
19
0
0
0
19
0
0
10
0
0
0
0
0
10
% K
% Leu:
0
0
0
0
10
0
0
19
28
0
10
0
10
10
0
% L
% Met:
0
0
0
0
0
10
0
10
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
10
10
0
% N
% Pro:
0
0
10
19
0
19
19
10
19
0
0
19
0
0
0
% P
% Gln:
19
0
0
0
0
0
0
0
0
0
0
10
19
28
19
% Q
% Arg:
28
0
46
10
37
28
28
28
0
28
19
10
10
0
10
% R
% Ser:
0
28
10
0
0
0
0
19
0
0
0
0
19
10
10
% S
% Thr:
10
10
19
0
10
0
10
10
19
0
10
10
0
0
0
% T
% Val:
0
10
0
28
28
0
10
0
10
28
10
0
0
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _