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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC2
All Species:
10
Human Site:
S322
Identified Species:
20
UniProt:
P18074
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18074
NP_000391.1
760
86909
S322
L
Q
E
A
V
P
G
S
I
R
T
A
E
H
F
Chimpanzee
Pan troglodytes
XP_001164105
760
86877
S322
L
Q
E
A
V
P
G
S
I
R
T
A
E
H
F
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_541562
641
72772
C243
A
H
N
I
D
N
V
C
I
D
S
M
S
V
N
Cat
Felis silvestris
Mouse
Mus musculus
O08811
760
86810
S322
L
Q
E
A
V
P
G
S
I
R
T
A
E
H
F
Rat
Rattus norvegicus
Q5RJZ1
1274
141760
D337
D
A
V
Q
L
P
G
D
D
R
G
V
T
K
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q3YK19
1252
140086
I492
N
H
F
H
D
M
G
I
T
N
I
S
F
P
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W484
985
109665
A349
M
Y
E
L
L
G
K
A
N
F
T
Y
G
N
V
Honey Bee
Apis mellifera
XP_396155
772
88880
N335
L
Q
E
V
V
P
G
N
I
R
N
A
E
H
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780825
683
77496
Y285
A
Q
R
L
R
E
E
Y
Q
R
L
V
D
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8W4M7
758
86217
N322
L
K
E
A
V
P
G
N
I
R
R
A
E
H
F
Baker's Yeast
Sacchar. cerevisiae
P06839
778
89768
N324
L
T
E
A
I
P
G
N
I
R
R
A
E
H
F
Red Bread Mold
Neurospora crassa
A7UXD4
1073
119198
E580
L
G
L
K
A
D
Q
E
G
I
V
L
D
T
S
Conservation
Percent
Protein Identity:
100
99.7
N.A.
82.3
N.A.
97.3
20.7
N.A.
N.A.
20.2
N.A.
N.A.
N.A.
20
70.3
N.A.
67.6
Protein Similarity:
100
100
N.A.
83.4
N.A.
98.9
33.2
N.A.
N.A.
33.7
N.A.
N.A.
N.A.
36.2
84.8
N.A.
80.1
P-Site Identity:
100
100
N.A.
6.6
N.A.
100
20
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
13.3
80
N.A.
13.3
P-Site Similarity:
100
100
N.A.
13.3
N.A.
100
26.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
40
86.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
54.7
51.1
21.1
Protein Similarity:
N.A.
N.A.
N.A.
73.2
71.3
35.7
P-Site Identity:
N.A.
N.A.
N.A.
80
73.3
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
93.3
86.6
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
9
0
42
9
0
0
9
0
0
0
50
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
17
9
0
9
9
9
0
0
17
0
0
% D
% Glu:
0
0
59
0
0
9
9
9
0
0
0
0
50
0
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
9
0
0
9
0
50
% F
% Gly:
0
9
0
0
0
9
67
0
9
0
9
0
9
9
0
% G
% His:
0
17
0
9
0
0
0
0
0
0
0
0
0
50
0
% H
% Ile:
0
0
0
9
9
0
0
9
59
9
9
0
0
0
9
% I
% Lys:
0
9
0
9
0
0
9
0
0
0
0
0
0
9
0
% K
% Leu:
59
0
9
17
17
0
0
0
0
0
9
9
0
0
9
% L
% Met:
9
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
0
9
0
0
9
0
25
9
9
9
0
0
9
9
% N
% Pro:
0
0
0
0
0
59
0
0
0
0
0
0
0
9
9
% P
% Gln:
0
42
0
9
0
0
9
0
9
0
0
0
0
0
0
% Q
% Arg:
0
0
9
0
9
0
0
0
0
67
17
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
25
0
0
9
9
9
0
9
% S
% Thr:
0
9
0
0
0
0
0
0
9
0
34
0
9
9
0
% T
% Val:
0
0
9
9
42
0
9
0
0
0
9
17
0
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _