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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC2
All Species:
20.3
Human Site:
S737
Identified Species:
40.61
UniProt:
P18074
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18074
NP_000391.1
760
86909
S737
R
E
D
Q
L
G
L
S
L
L
S
L
E
Q
L
Chimpanzee
Pan troglodytes
XP_001164105
760
86877
S737
R
E
D
Q
L
G
L
S
L
L
S
L
E
Q
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_541562
641
72772
G622
G
R
A
V
I
M
F
G
V
P
Y
V
Y
T
Q
Cat
Felis silvestris
Mouse
Mus musculus
O08811
760
86810
S737
R
E
D
Q
L
G
L
S
L
L
S
L
E
Q
L
Rat
Rattus norvegicus
Q5RJZ1
1274
141760
K1179
K
P
E
K
T
Q
S
K
I
S
S
F
L
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q3YK19
1252
140086
S1204
L
S
D
I
S
K
N
S
T
V
N
I
E
K
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W484
985
109665
S871
K
I
H
K
R
E
R
S
S
P
T
A
P
E
S
Honey Bee
Apis mellifera
XP_396155
772
88880
S750
R
E
N
Q
L
G
L
S
L
L
T
R
E
Q
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780825
683
77496
C664
A
M
R
H
A
A
Q
C
V
G
R
A
L
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8W4M7
758
86217
K737
K
A
G
T
M
G
R
K
T
L
L
T
Q
E
D
Baker's Yeast
Sacchar. cerevisiae
P06839
778
89768
S737
P
K
D
Q
E
G
V
S
V
W
S
Y
E
D
L
Red Bread Mold
Neurospora crassa
A7UXD4
1073
119198
K1027
E
K
E
H
V
R
A
K
L
P
G
W
I
R
E
Conservation
Percent
Protein Identity:
100
99.7
N.A.
82.3
N.A.
97.3
20.7
N.A.
N.A.
20.2
N.A.
N.A.
N.A.
20
70.3
N.A.
67.6
Protein Similarity:
100
100
N.A.
83.4
N.A.
98.9
33.2
N.A.
N.A.
33.7
N.A.
N.A.
N.A.
36.2
84.8
N.A.
80.1
P-Site Identity:
100
100
N.A.
0
N.A.
100
6.6
N.A.
N.A.
20
N.A.
N.A.
N.A.
6.6
80
N.A.
0
P-Site Similarity:
100
100
N.A.
20
N.A.
100
40
N.A.
N.A.
53.3
N.A.
N.A.
N.A.
33.3
93.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
54.7
51.1
21.1
Protein Similarity:
N.A.
N.A.
N.A.
73.2
71.3
35.7
P-Site Identity:
N.A.
N.A.
N.A.
13.3
46.6
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
40
66.6
33.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
9
0
9
9
9
0
0
0
0
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
0
42
0
0
0
0
0
0
0
0
0
0
9
9
% D
% Glu:
9
34
17
0
9
9
0
0
0
0
0
0
50
17
9
% E
% Phe:
0
0
0
0
0
0
9
0
0
0
0
9
0
0
0
% F
% Gly:
9
0
9
0
0
50
0
9
0
9
9
0
0
0
9
% G
% His:
0
0
9
17
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
9
9
0
0
0
9
0
0
9
9
0
0
% I
% Lys:
25
17
0
17
0
9
0
25
0
0
0
0
0
9
0
% K
% Leu:
9
0
0
0
34
0
34
0
42
42
9
25
17
0
42
% L
% Met:
0
9
0
0
9
9
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
9
0
0
0
9
0
0
0
9
0
0
0
0
% N
% Pro:
9
9
0
0
0
0
0
0
0
25
0
0
9
0
0
% P
% Gln:
0
0
0
42
0
9
9
0
0
0
0
0
9
34
17
% Q
% Arg:
34
9
9
0
9
9
17
0
0
0
9
9
0
25
0
% R
% Ser:
0
9
0
0
9
0
9
59
9
9
42
0
0
0
9
% S
% Thr:
0
0
0
9
9
0
0
0
17
0
17
9
0
9
0
% T
% Val:
0
0
0
9
9
0
9
0
25
9
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
9
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
9
9
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _