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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC2 All Species: 19.7
Human Site: S740 Identified Species: 39.39
UniProt: P18074 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18074 NP_000391.1 760 86909 S740 Q L G L S L L S L E Q L E S E
Chimpanzee Pan troglodytes XP_001164105 760 86877 S740 Q L G L S L L S L E Q L E S E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_541562 641 72772 Y625 V I M F G V P Y V Y T Q S R I
Cat Felis silvestris
Mouse Mus musculus O08811 760 86810 S740 Q L G L S L L S L E Q L Q S E
Rat Rattus norvegicus Q5RJZ1 1274 141760 S1182 K T Q S K I S S F L R Q R P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q3YK19 1252 140086 N1207 I S K N S T V N I E K M T N G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W484 985 109665 T874 K R E R S S P T A P E S S S Q
Honey Bee Apis mellifera XP_396155 772 88880 T753 Q L G L S L L T R E Q L E K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780825 683 77496 R667 H A A Q C V G R A L R G K T D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W4M7 758 86217 L740 T M G R K T L L T Q E D L E K
Baker's Yeast Sacchar. cerevisiae P06839 778 89768 S740 Q E G V S V W S Y E D L I K H
Red Bread Mold Neurospora crassa A7UXD4 1073 119198 G1030 H V R A K L P G W I R E G W D
Conservation
Percent
Protein Identity: 100 99.7 N.A. 82.3 N.A. 97.3 20.7 N.A. N.A. 20.2 N.A. N.A. N.A. 20 70.3 N.A. 67.6
Protein Similarity: 100 100 N.A. 83.4 N.A. 98.9 33.2 N.A. N.A. 33.7 N.A. N.A. N.A. 36.2 84.8 N.A. 80.1
P-Site Identity: 100 100 N.A. 0 N.A. 93.3 6.6 N.A. N.A. 13.3 N.A. N.A. N.A. 13.3 80 N.A. 0
P-Site Similarity: 100 100 N.A. 20 N.A. 100 33.3 N.A. N.A. 53.3 N.A. N.A. N.A. 40 86.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. 54.7 51.1 21.1
Protein Similarity: N.A. N.A. N.A. 73.2 71.3 35.7
P-Site Identity: N.A. N.A. N.A. 13.3 40 6.6
P-Site Similarity: N.A. N.A. N.A. 40 53.3 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 9 0 0 0 0 17 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 25 % D
% Glu: 0 9 9 0 0 0 0 0 0 50 17 9 25 9 34 % E
% Phe: 0 0 0 9 0 0 0 0 9 0 0 0 0 0 0 % F
% Gly: 0 0 50 0 9 0 9 9 0 0 0 9 9 0 9 % G
% His: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 9 9 0 0 0 9 0 0 9 9 0 0 9 0 9 % I
% Lys: 17 0 9 0 25 0 0 0 0 0 9 0 9 17 9 % K
% Leu: 0 34 0 34 0 42 42 9 25 17 0 42 9 0 0 % L
% Met: 0 9 9 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 0 0 0 9 0 0 0 9 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 0 25 0 0 9 0 0 0 9 0 % P
% Gln: 42 0 9 9 0 0 0 0 0 9 34 17 9 0 9 % Q
% Arg: 0 9 9 17 0 0 0 9 9 0 25 0 9 9 0 % R
% Ser: 0 9 0 9 59 9 9 42 0 0 0 9 17 34 0 % S
% Thr: 9 9 0 0 0 17 0 17 9 0 9 0 9 9 0 % T
% Val: 9 9 0 9 0 25 9 0 9 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 9 0 9 0 0 0 0 9 0 % W
% Tyr: 0 0 0 0 0 0 0 9 9 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _