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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ERCC2 All Species: 17.27
Human Site: T252 Identified Species: 34.55
UniProt: P18074 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18074 NP_000391.1 760 86909 T252 D S M S V N L T R R T L D R C
Chimpanzee Pan troglodytes XP_001164105 760 86877 T252 D S M S V N L T R R T L D R C
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_541562 641 72772 D179 A G I Y N L D D L K A L G Q R
Cat Felis silvestris
Mouse Mus musculus O08811 760 86810 T252 D S M S V N L T R R T L D R C
Rat Rattus norvegicus Q5RJZ1 1274 141760 T268 E S A S F D L T P R D V A S G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q3YK19 1252 140086 T421 E A V S Y S V T E S Q L N A A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9W484 985 109665 K270 E S A S V Q I K S S D V A M A
Honey Bee Apis mellifera XP_396155 772 88880 N265 D S M S V K I N R R T L E K S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780825 683 77496 V221 D P K I A E Q V S K E L S K Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W4M7 758 86217 R252 E A L S V S V R R V T L E G A
Baker's Yeast Sacchar. cerevisiae P06839 778 89768 T253 E S L S L D L T T D A L R R A
Red Bread Mold Neurospora crassa A7UXD4 1073 119198 N513 N I M D A V S N V H A A E I K
Conservation
Percent
Protein Identity: 100 99.7 N.A. 82.3 N.A. 97.3 20.7 N.A. N.A. 20.2 N.A. N.A. N.A. 20 70.3 N.A. 67.6
Protein Similarity: 100 100 N.A. 83.4 N.A. 98.9 33.2 N.A. N.A. 33.7 N.A. N.A. N.A. 36.2 84.8 N.A. 80.1
P-Site Identity: 100 100 N.A. 6.6 N.A. 100 33.3 N.A. N.A. 20 N.A. N.A. N.A. 20 60 N.A. 13.3
P-Site Similarity: 100 100 N.A. 26.6 N.A. 100 53.3 N.A. N.A. 60 N.A. N.A. N.A. 40 80 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 54.7 51.1 21.1
Protein Similarity: N.A. N.A. N.A. 73.2 71.3 35.7
P-Site Identity: N.A. N.A. N.A. 33.3 40 6.6
P-Site Similarity: N.A. N.A. N.A. 73.3 66.6 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 17 17 0 17 0 0 0 0 0 25 9 17 9 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 % C
% Asp: 42 0 0 9 0 17 9 9 0 9 17 0 25 0 0 % D
% Glu: 42 0 0 0 0 9 0 0 9 0 9 0 25 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 9 0 0 0 0 0 0 0 0 0 0 9 9 9 % G
% His: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 0 9 9 9 0 0 17 0 0 0 0 0 0 9 0 % I
% Lys: 0 0 9 0 0 9 0 9 0 17 0 0 0 17 9 % K
% Leu: 0 0 17 0 9 9 42 0 9 0 0 75 0 0 0 % L
% Met: 0 0 42 0 0 0 0 0 0 0 0 0 0 9 0 % M
% Asn: 9 0 0 0 9 25 0 17 0 0 0 0 9 0 0 % N
% Pro: 0 9 0 0 0 0 0 0 9 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 9 9 0 0 0 9 0 0 9 9 % Q
% Arg: 0 0 0 0 0 0 0 9 42 42 0 0 9 34 9 % R
% Ser: 0 59 0 75 0 17 9 0 17 17 0 0 9 9 9 % S
% Thr: 0 0 0 0 0 0 0 50 9 0 42 0 0 0 0 % T
% Val: 0 0 9 0 50 9 17 9 9 9 0 17 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _