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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ERCC2
All Species:
16.06
Human Site:
Y175
Identified Species:
32.12
UniProt:
P18074
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18074
NP_000391.1
760
86909
Y175
V
P
L
P
A
G
I
Y
N
L
D
D
L
K
A
Chimpanzee
Pan troglodytes
XP_001164105
760
86877
Y175
V
P
L
P
A
G
I
Y
N
L
D
D
L
K
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_541562
641
72772
K113
G
L
A
L
S
S
R
K
N
L
C
I
H
P
E
Cat
Felis silvestris
Mouse
Mus musculus
O08811
760
86810
Y175
M
P
L
P
A
G
I
Y
N
L
D
D
L
K
A
Rat
Rattus norvegicus
Q5RJZ1
1274
141760
L192
Q
E
L
A
T
P
I
L
D
I
E
D
L
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q3YK19
1252
140086
W345
A
H
N
T
Y
Q
A
W
D
I
E
D
L
V
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W484
985
109665
D195
L
R
G
P
T
I
M
D
I
E
D
L
V
K
V
Honey Bee
Apis mellifera
XP_396155
772
88880
Y188
Q
I
M
P
S
G
I
Y
S
I
D
D
L
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780825
683
77496
C155
H
D
P
A
V
P
I
C
D
F
Y
E
E
F
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8W4M7
758
86217
Y175
A
L
L
P
P
G
V
Y
T
L
E
D
L
R
A
Baker's Yeast
Sacchar. cerevisiae
P06839
778
89768
F176
D
Y
L
P
K
G
V
F
S
F
E
K
L
L
K
Red Bread Mold
Neurospora crassa
A7UXD4
1073
119198
P444
D
T
A
L
A
T
L
P
D
I
E
D
L
Y
Q
Conservation
Percent
Protein Identity:
100
99.7
N.A.
82.3
N.A.
97.3
20.7
N.A.
N.A.
20.2
N.A.
N.A.
N.A.
20
70.3
N.A.
67.6
Protein Similarity:
100
100
N.A.
83.4
N.A.
98.9
33.2
N.A.
N.A.
33.7
N.A.
N.A.
N.A.
36.2
84.8
N.A.
80.1
P-Site Identity:
100
100
N.A.
13.3
N.A.
93.3
26.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
20
53.3
N.A.
6.6
P-Site Similarity:
100
100
N.A.
20
N.A.
100
46.6
N.A.
N.A.
46.6
N.A.
N.A.
N.A.
40
80
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
54.7
51.1
21.1
Protein Similarity:
N.A.
N.A.
N.A.
73.2
71.3
35.7
P-Site Identity:
N.A.
N.A.
N.A.
53.3
26.6
20
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
53.3
46.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
17
17
34
0
9
0
0
0
0
0
0
0
34
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
9
0
0
0
0
% C
% Asp:
17
9
0
0
0
0
0
9
34
0
42
67
0
0
9
% D
% Glu:
0
9
0
0
0
0
0
0
0
9
42
9
9
0
17
% E
% Phe:
0
0
0
0
0
0
0
9
0
17
0
0
0
9
0
% F
% Gly:
9
0
9
0
0
50
0
0
0
0
0
0
0
0
0
% G
% His:
9
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
9
0
0
0
9
50
0
9
34
0
9
0
0
0
% I
% Lys:
0
0
0
0
9
0
0
9
0
0
0
9
0
42
17
% K
% Leu:
9
17
50
17
0
0
9
9
0
42
0
9
75
9
0
% L
% Met:
9
0
9
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
34
0
0
0
0
0
0
% N
% Pro:
0
25
9
59
9
17
0
9
0
0
0
0
0
9
0
% P
% Gln:
17
0
0
0
0
9
0
0
0
0
0
0
0
0
9
% Q
% Arg:
0
9
0
0
0
0
9
0
0
0
0
0
0
9
0
% R
% Ser:
0
0
0
0
17
9
0
0
17
0
0
0
0
0
9
% S
% Thr:
0
9
0
9
17
9
0
0
9
0
0
0
0
0
0
% T
% Val:
17
0
0
0
9
0
17
0
0
0
0
0
9
17
9
% V
% Trp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% W
% Tyr:
0
9
0
0
9
0
0
42
0
0
9
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _