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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2B
All Species:
11.52
Human Site:
S218
Identified Species:
21.11
UniProt:
P18089
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18089
NP_000673.2
450
49954
S218
G
G
P
G
Q
G
E
S
K
Q
P
R
P
D
H
Chimpanzee
Pan troglodytes
XP_515627
843
90504
S613
G
G
P
G
Q
G
E
S
K
Q
P
R
P
D
H
Rhesus Macaque
Macaca mulatta
XP_001082230
445
49417
S218
G
G
P
G
Q
G
E
S
K
Q
P
R
P
N
R
Dog
Lupus familis
XP_854447
444
49208
G216
A
A
G
G
R
G
E
G
E
S
K
Q
P
H
S
Cat
Felis silvestris
Mouse
Mus musculus
P30545
450
50154
P221
G
E
G
E
S
K
K
P
R
P
G
P
A
A
G
Rat
Rattus norvegicus
P19328
453
50351
K224
G
S
G
E
G
E
S
K
K
P
Q
P
V
A
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514931
210
22727
V19
L
A
A
A
D
I
L
V
A
T
L
I
I
P
F
Chicken
Gallus gallus
XP_426355
614
69002
S415
R
T
M
P
E
G
S
S
Q
T
E
N
G
L
S
Frog
Xenopus laevis
P24628
442
49720
K232
G
V
A
V
D
A
H
K
D
K
C
T
H
P
E
Zebra Danio
Brachydanio rerio
Q90WY5
510
55953
G266
G
R
G
D
E
T
P
G
T
L
Q
K
K
A
R
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
K222
V
L
Y
G
R
I
F
K
A
A
R
F
R
I
R
Fruit Fly
Dros. melanogaster
P22270
601
64656
S398
V
V
V
L
V
K
K
S
R
R
A
K
T
K
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
N258
S
K
R
T
N
G
K
N
M
I
A
S
E
C
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.7
96.2
90
N.A.
83.1
83.6
N.A.
40
25.8
30.8
50.9
31.5
28.4
N.A.
N.A.
33.7
Protein Similarity:
100
51.2
96.8
93.1
N.A.
88.4
89.4
N.A.
41.7
36.8
53.1
62.1
51.3
42.5
N.A.
N.A.
51.8
P-Site Identity:
100
100
86.6
26.6
N.A.
6.6
13.3
N.A.
0
13.3
6.6
6.6
6.6
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
46.6
N.A.
20
13.3
N.A.
0
26.6
13.3
20
13.3
33.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
16
8
0
8
0
0
16
8
16
0
8
24
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% C
% Asp:
0
0
0
8
16
0
0
0
8
0
0
0
0
16
8
% D
% Glu:
0
8
0
16
16
8
31
0
8
0
8
0
8
0
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
8
% F
% Gly:
54
24
31
39
8
47
0
16
0
0
8
0
8
0
16
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
8
8
16
% H
% Ile:
0
0
0
0
0
16
0
0
0
8
0
8
8
8
8
% I
% Lys:
0
8
0
0
0
16
24
24
31
8
8
16
8
8
0
% K
% Leu:
8
8
0
8
0
0
8
0
0
8
8
0
0
8
0
% L
% Met:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
0
0
8
0
8
0
% N
% Pro:
0
0
24
8
0
0
8
8
0
16
24
16
31
16
0
% P
% Gln:
0
0
0
0
24
0
0
0
8
24
16
8
0
0
0
% Q
% Arg:
8
8
8
0
16
0
0
0
16
8
8
24
8
0
24
% R
% Ser:
8
8
0
0
8
0
16
39
0
8
0
8
0
0
16
% S
% Thr:
0
8
0
8
0
8
0
0
8
16
0
8
8
0
0
% T
% Val:
16
16
8
8
8
0
0
8
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _