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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2B
All Species:
16.36
Human Site:
S242
Identified Species:
30
UniProt:
P18089
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18089
NP_000673.2
450
49954
S242
P
A
L
A
S
V
A
S
A
R
E
V
N
G
H
Chimpanzee
Pan troglodytes
XP_515627
843
90504
S637
P
A
L
A
S
L
A
S
A
R
E
V
N
G
H
Rhesus Macaque
Macaca mulatta
XP_001082230
445
49417
S242
P
A
L
A
S
L
A
S
A
R
E
V
N
G
H
Dog
Lupus familis
XP_854447
444
49208
A240
P
T
L
A
S
L
A
A
S
G
E
A
N
G
H
Cat
Felis silvestris
Mouse
Mus musculus
P30545
450
50154
S245
T
L
V
S
P
L
S
S
V
G
E
A
N
G
H
Rat
Rattus norvegicus
P19328
453
50351
S248
T
L
V
S
P
L
S
S
V
G
E
A
N
G
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514931
210
22727
C43
W
Y
F
R
H
T
W
C
E
V
Y
L
A
L
D
Chicken
Gallus gallus
XP_426355
614
69002
G439
R
M
Q
L
G
E
N
G
H
Y
S
V
H
H
W
Frog
Xenopus laevis
P24628
442
49720
A256
K
S
N
G
S
F
P
A
D
K
K
K
V
I
L
Zebra Danio
Brachydanio rerio
Q90WY5
510
55953
N290
E
S
V
Q
Q
A
A
N
T
P
I
A
N
N
L
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
A246
K
V
S
D
T
C
L
A
L
S
P
A
M
F
H
Fruit Fly
Dros. melanogaster
P22270
601
64656
S422
G
R
K
S
Q
S
S
S
T
C
E
P
H
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
H282
G
K
T
Y
A
M
I
H
K
A
D
P
D
I
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.7
96.2
90
N.A.
83.1
83.6
N.A.
40
25.8
30.8
50.9
31.5
28.4
N.A.
N.A.
33.7
Protein Similarity:
100
51.2
96.8
93.1
N.A.
88.4
89.4
N.A.
41.7
36.8
53.1
62.1
51.3
42.5
N.A.
N.A.
51.8
P-Site Identity:
100
93.3
93.3
60
N.A.
33.3
33.3
N.A.
0
6.6
6.6
13.3
6.6
20
N.A.
N.A.
0
P-Site Similarity:
100
100
100
80
N.A.
60
60
N.A.
6.6
13.3
33.3
33.3
20
40
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
24
0
31
8
8
39
24
24
8
0
39
8
0
0
% A
% Cys:
0
0
0
0
0
8
0
8
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
8
0
8
0
8
% D
% Glu:
8
0
0
0
0
8
0
0
8
0
54
0
0
0
8
% E
% Phe:
0
0
8
0
0
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
16
0
0
8
8
0
0
8
0
24
0
0
0
54
0
% G
% His:
0
0
0
0
8
0
0
8
8
0
0
0
16
8
54
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
8
0
0
16
0
% I
% Lys:
16
8
8
0
0
0
0
0
8
8
8
8
0
0
0
% K
% Leu:
0
16
31
8
0
39
8
0
8
0
0
8
0
8
16
% L
% Met:
0
8
0
0
0
8
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
8
0
0
0
8
8
0
0
0
0
54
8
0
% N
% Pro:
31
0
0
0
16
0
8
0
0
8
8
16
0
0
0
% P
% Gln:
0
0
8
8
16
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
8
8
0
8
0
0
0
0
0
24
0
0
0
0
0
% R
% Ser:
0
16
8
24
39
8
24
47
8
8
8
0
0
0
0
% S
% Thr:
16
8
8
0
8
8
0
0
16
0
0
0
0
0
0
% T
% Val:
0
8
24
0
0
8
0
0
16
8
0
31
8
0
0
% V
% Trp:
8
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% W
% Tyr:
0
8
0
8
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _