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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2B
All Species:
11.82
Human Site:
S252
Identified Species:
21.67
UniProt:
P18089
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18089
NP_000673.2
450
49954
S252
E
V
N
G
H
S
K
S
T
G
E
K
E
E
G
Chimpanzee
Pan troglodytes
XP_515627
843
90504
S647
E
V
N
G
H
S
K
S
T
G
E
K
E
E
G
Rhesus Macaque
Macaca mulatta
XP_001082230
445
49417
S252
E
V
N
G
H
S
K
S
T
G
E
K
E
E
G
Dog
Lupus familis
XP_854447
444
49208
P250
E
A
N
G
H
S
K
P
T
G
E
K
E
E
G
Cat
Felis silvestris
Mouse
Mus musculus
P30545
450
50154
P255
E
A
N
G
H
P
K
P
P
R
E
K
E
E
G
Rat
Rattus norvegicus
P19328
453
50351
P258
E
A
N
G
H
P
K
P
P
R
E
K
E
E
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514931
210
22727
F53
Y
L
A
L
D
V
L
F
C
T
S
S
I
V
H
Chicken
Gallus gallus
XP_426355
614
69002
A449
S
V
H
H
W
R
K
A
S
E
L
E
D
I
E
Frog
Xenopus laevis
P24628
442
49720
E266
K
K
V
I
L
V
Q
E
A
G
K
H
P
E
D
Zebra Danio
Brachydanio rerio
Q90WY5
510
55953
A300
I
A
N
N
L
L
Q
A
P
S
T
T
L
T
P
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
T256
P
A
M
F
H
R
K
T
P
G
D
A
H
G
K
Fruit Fly
Dros. melanogaster
P22270
601
64656
L432
E
P
H
G
E
Q
Q
L
L
P
A
G
G
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
T292
D
P
D
I
Q
M
A
T
L
Q
V
D
H
E
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.7
96.2
90
N.A.
83.1
83.6
N.A.
40
25.8
30.8
50.9
31.5
28.4
N.A.
N.A.
33.7
Protein Similarity:
100
51.2
96.8
93.1
N.A.
88.4
89.4
N.A.
41.7
36.8
53.1
62.1
51.3
42.5
N.A.
N.A.
51.8
P-Site Identity:
100
100
100
86.6
N.A.
66.6
66.6
N.A.
0
13.3
13.3
6.6
20
20
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
86.6
N.A.
66.6
66.6
N.A.
6.6
46.6
33.3
20
33.3
40
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
39
8
0
0
0
8
16
8
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
8
0
0
0
0
0
8
8
8
8
8
% D
% Glu:
54
0
0
0
8
0
0
8
0
8
47
8
47
62
8
% E
% Phe:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
54
0
0
0
0
0
47
0
8
8
8
54
% G
% His:
0
0
16
8
54
0
0
0
0
0
0
8
16
0
16
% H
% Ile:
8
0
0
16
0
0
0
0
0
0
0
0
8
8
0
% I
% Lys:
8
8
0
0
0
0
62
0
0
0
8
47
0
0
8
% K
% Leu:
0
8
0
8
16
8
8
8
16
0
8
0
8
0
0
% L
% Met:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
54
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
8
16
0
0
0
16
0
24
31
8
0
0
8
0
8
% P
% Gln:
0
0
0
0
8
8
24
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
16
0
0
0
16
0
0
0
0
0
% R
% Ser:
8
0
0
0
0
31
0
24
8
8
8
8
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
16
31
8
8
8
0
8
0
% T
% Val:
0
31
8
0
0
16
0
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _