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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2B
All Species:
21.52
Human Site:
S318
Identified Species:
39.44
UniProt:
P18089
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18089
NP_000673.2
450
49954
S318
E
P
Q
A
V
P
V
S
P
A
S
A
C
S
P
Chimpanzee
Pan troglodytes
XP_515627
843
90504
S711
E
P
Q
A
V
P
V
S
P
A
S
A
C
S
P
Rhesus Macaque
Macaca mulatta
XP_001082230
445
49417
S313
E
P
Q
E
G
P
V
S
A
A
S
A
C
S
P
Dog
Lupus familis
XP_854447
444
49208
S312
E
P
Q
A
L
P
A
S
P
A
A
A
C
S
P
Cat
Felis silvestris
Mouse
Mus musculus
P30545
450
50154
S318
E
P
Q
T
L
P
A
S
P
A
S
V
F
N
P
Rat
Rattus norvegicus
P19328
453
50351
S321
E
P
Q
T
L
P
A
S
P
A
S
V
C
N
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514931
210
22727
Y108
I
S
L
P
P
L
V
Y
K
G
D
K
G
P
R
Chicken
Gallus gallus
XP_426355
614
69002
S504
L
S
R
S
S
N
R
S
M
E
F
F
S
Y
R
Frog
Xenopus laevis
P24628
442
49720
A324
P
V
E
S
P
Y
K
A
E
K
N
G
H
P
K
Zebra Danio
Brachydanio rerio
Q90WY5
510
55953
M377
E
V
P
C
T
P
T
M
T
P
S
G
I
H
S
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
T311
P
L
P
N
T
P
G
T
V
P
L
F
E
N
R
Fruit Fly
Dros. melanogaster
P22270
601
64656
P487
Q
T
S
L
K
L
T
P
P
Q
S
S
T
G
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
M349
T
S
L
L
P
P
G
M
R
A
S
D
T
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.7
96.2
90
N.A.
83.1
83.6
N.A.
40
25.8
30.8
50.9
31.5
28.4
N.A.
N.A.
33.7
Protein Similarity:
100
51.2
96.8
93.1
N.A.
88.4
89.4
N.A.
41.7
36.8
53.1
62.1
51.3
42.5
N.A.
N.A.
51.8
P-Site Identity:
100
100
80
80
N.A.
60
66.6
N.A.
6.6
6.6
0
20
6.6
13.3
N.A.
N.A.
20
P-Site Similarity:
100
100
80
93.3
N.A.
73.3
80
N.A.
6.6
20
26.6
20
20
26.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
24
0
0
24
8
8
54
8
31
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
39
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
0
% D
% Glu:
54
0
8
8
0
0
0
0
8
8
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
16
8
0
0
% F
% Gly:
0
0
0
0
8
0
16
0
0
8
0
16
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
16
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
8
0
8
0
8
8
0
8
0
0
8
% K
% Leu:
8
8
16
16
24
16
0
0
0
0
8
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
16
8
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
8
0
0
0
0
8
0
0
24
0
% N
% Pro:
16
47
16
8
24
70
0
8
47
16
0
0
0
16
47
% P
% Gln:
8
0
47
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
8
0
8
0
0
0
0
0
24
% R
% Ser:
0
24
8
16
8
0
0
54
0
0
62
8
8
31
8
% S
% Thr:
8
8
0
16
16
0
16
8
8
0
0
0
16
0
0
% T
% Val:
0
16
0
0
16
0
31
0
8
0
0
16
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
8
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _