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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2B
All Species:
31.52
Human Site:
Y172
Identified Species:
57.78
UniProt:
P18089
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18089
NP_000673.2
450
49954
Y172
K
L
N
Q
E
A
W
Y
I
L
A
S
S
I
G
Chimpanzee
Pan troglodytes
XP_515627
843
90504
Y567
K
L
N
Q
E
A
W
Y
I
L
A
S
S
I
G
Rhesus Macaque
Macaca mulatta
XP_001082230
445
49417
Y172
K
L
N
Q
E
A
W
Y
I
L
A
S
S
I
G
Dog
Lupus familis
XP_854447
444
49208
W171
C
K
L
N
Q
E
A
W
Y
I
L
A
S
S
I
Cat
Felis silvestris
Mouse
Mus musculus
P30545
450
50154
Y172
E
L
N
Q
E
A
W
Y
I
L
A
S
S
I
G
Rat
Rattus norvegicus
P19328
453
50351
Y177
E
L
N
Q
E
A
W
Y
I
L
A
S
S
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514931
210
22727
Chicken
Gallus gallus
XP_426355
614
69002
Y370
K
L
N
D
E
T
W
Y
I
L
S
S
C
I
V
Frog
Xenopus laevis
P24628
442
49720
F183
C
I
I
D
N
P
A
F
V
I
Y
S
S
I
V
Zebra Danio
Brachydanio rerio
Q90WY5
510
55953
Y203
Q
L
N
D
E
R
W
Y
I
L
Y
S
T
I
G
Tiger Blowfish
Takifugu rubipres
O42384
416
47013
P176
M
L
I
M
R
S
Q
P
S
S
M
A
E
D
R
Fruit Fly
Dros. melanogaster
P22270
601
64656
Y269
E
L
T
S
Q
R
G
Y
V
I
Y
S
S
L
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
Y213
V
I
S
E
D
I
G
Y
I
L
Y
S
T
M
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.7
96.2
90
N.A.
83.1
83.6
N.A.
40
25.8
30.8
50.9
31.5
28.4
N.A.
N.A.
33.7
Protein Similarity:
100
51.2
96.8
93.1
N.A.
88.4
89.4
N.A.
41.7
36.8
53.1
62.1
51.3
42.5
N.A.
N.A.
51.8
P-Site Identity:
100
100
100
6.6
N.A.
93.3
93.3
N.A.
0
66.6
20
66.6
6.6
33.3
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
33.3
N.A.
100
100
N.A.
0
73.3
46.6
80
20
66.6
N.A.
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
39
16
0
0
0
39
16
0
0
0
% A
% Cys:
16
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
24
8
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
24
0
0
8
54
8
0
0
0
0
0
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
62
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
16
16
0
0
8
0
0
62
24
0
0
0
62
8
% I
% Lys:
31
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
70
8
0
0
0
0
0
0
62
8
0
0
8
0
% L
% Met:
8
0
0
8
0
0
0
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
54
8
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
39
16
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
8
16
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
8
8
0
8
0
0
8
8
8
77
62
8
0
% S
% Thr:
0
0
8
0
0
8
0
0
0
0
0
0
16
0
0
% T
% Val:
8
0
0
0
0
0
0
0
16
0
0
0
0
0
16
% V
% Trp:
0
0
0
0
0
0
54
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
70
8
0
31
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _