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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RCC1 All Species: 19.39
Human Site: S236 Identified Species: 35.56
UniProt: P18754 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P18754 NP_001041659.1 421 44969 S236 V M L K S R G S R G H V R F Q
Chimpanzee Pan troglodytes XP_001152659 421 44920 S236 V M L K S R G S R G H V R F Q
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_544458 630 67681 S445 V M L K S R G S R G H V R F Q
Cat Felis silvestris
Mouse Mus musculus Q8VE37 421 44912 T236 V L L K S R G T R G R V R F Q
Rat Rattus norvegicus NP_001121661 421 45093 T236 V L L K S R G T R G R V R F Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_427366 194 21051 K11 V C L S E T G K I Y T F G C N
Frog Xenopus laevis P25183 424 45052 G241 C I H L K A K G S G R V H F Q
Zebra Danio Brachydanio rerio Q6NYE2 495 54133 P299 T K D G Q V L P V P N V V A R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P25171 547 58832 L235 D L L R P T Q L I I T R A K P
Honey Bee Apis mellifera XP_394158 439 46956 T249 G L V E F K V T K K L E F D D
Nematode Worm Caenorhab. elegans Q18211 569 61466 K365 L R F K H K G K F F D V V A K
Sea Urchin Strong. purpuratus XP_001191815 424 45249 K241 I C K R V R G K G K V M F D G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P21827 482 52995 H285 Y I A S G E N H C F A L T K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 64.7 N.A. 93.8 93.3 N.A. N.A. 37 75.9 22.2 N.A. 29 45.5 29.5 52.8
Protein Similarity: 100 99.7 N.A. 65.8 N.A. 96.9 96.6 N.A. N.A. 42 85.6 40 N.A. 43.6 63 42.5 70.7
P-Site Identity: 100 100 N.A. 100 N.A. 80 80 N.A. N.A. 20 26.6 6.6 N.A. 6.6 0 20 13.3
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. N.A. 20 33.3 20 N.A. 20 40 40 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 8 0 0 0 0 8 0 8 16 0 % A
% Cys: 8 16 0 0 0 0 0 0 8 0 0 0 0 8 0 % C
% Asp: 8 0 8 0 0 0 0 0 0 0 8 0 0 16 16 % D
% Glu: 0 0 0 8 8 8 0 0 0 0 0 8 0 0 0 % E
% Phe: 0 0 8 0 8 0 0 0 8 16 0 8 16 47 0 % F
% Gly: 8 0 0 8 8 0 62 8 8 47 0 0 8 0 8 % G
% His: 0 0 8 0 8 0 0 8 0 0 24 0 8 0 0 % H
% Ile: 8 16 0 0 0 0 0 0 16 8 0 0 0 0 0 % I
% Lys: 0 8 8 47 8 16 8 24 8 16 0 0 0 16 8 % K
% Leu: 8 31 54 8 0 0 8 8 0 0 8 8 0 0 0 % L
% Met: 0 24 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 0 0 8 0 0 0 8 % N
% Pro: 0 0 0 0 8 0 0 8 0 8 0 0 0 0 8 % P
% Gln: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 47 % Q
% Arg: 0 8 0 16 0 47 0 0 39 0 24 8 39 0 8 % R
% Ser: 0 0 0 16 39 0 0 24 8 0 0 0 0 0 0 % S
% Thr: 8 0 0 0 0 16 0 24 0 0 16 0 8 0 0 % T
% Val: 47 0 8 0 8 8 8 0 8 0 8 62 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _