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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2C
All Species:
23.03
Human Site:
S189
Identified Species:
50.67
UniProt:
P18825
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18825
NP_000674.2
462
49522
S189
I
S
F
P
P
L
V
S
L
Y
R
Q
P
D
G
Chimpanzee
Pan troglodytes
Q9N298
422
46153
T188
R
S
D
P
D
A
C
T
I
S
K
D
H
G
Y
Rhesus Macaque
Macaca mulatta
XP_001114432
408
42792
S187
I
S
F
P
P
L
V
S
L
Y
R
Q
P
D
G
Dog
Lupus familis
XP_545911
714
73976
S194
I
S
F
P
P
L
V
S
L
Y
R
Q
P
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01337
458
49888
S189
I
S
F
P
P
L
V
S
F
Y
R
R
P
D
G
Rat
Rattus norvegicus
P22086
458
49846
S189
I
S
F
P
P
L
V
S
F
Y
R
R
P
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519776
218
24278
Chicken
Gallus gallus
XP_426355
614
69002
S349
I
S
F
P
P
L
I
S
M
Y
R
D
P
E
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q90WY6
432
49119
Q187
D
E
R
R
P
M
C
Q
L
N
D
H
T
W
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22270
601
64656
G247
I
S
S
P
P
L
I
G
W
N
D
W
P
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
G190
I
S
V
P
P
L
F
G
W
R
S
E
I
K
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.9
80.3
59.6
N.A.
92.8
93
N.A.
35.9
53.7
N.A.
58.4
N.A.
32.7
N.A.
N.A.
33.3
Protein Similarity:
100
50
80.9
61.6
N.A.
93.5
93.7
N.A.
39.1
60.2
N.A.
70.1
N.A.
47.5
N.A.
N.A.
52.2
P-Site Identity:
100
13.3
100
93.3
N.A.
86.6
86.6
N.A.
0
73.3
N.A.
13.3
N.A.
46.6
N.A.
N.A.
33.3
P-Site Similarity:
100
33.3
100
93.3
N.A.
93.3
93.3
N.A.
0
93.3
N.A.
20
N.A.
53.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
10
0
0
0
0
0
19
19
0
55
0
% D
% Glu:
0
10
0
0
0
0
0
0
0
0
0
10
0
10
10
% E
% Phe:
0
0
55
0
0
0
10
0
19
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
19
0
0
0
0
0
10
46
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% H
% Ile:
73
0
0
0
0
0
19
0
10
0
0
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% K
% Leu:
0
0
0
0
0
73
0
0
37
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
10
% M
% Asn:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% N
% Pro:
0
0
0
82
82
0
0
0
0
0
0
0
64
0
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
0
28
0
0
0
% Q
% Arg:
10
0
10
10
0
0
0
0
0
10
55
19
0
0
0
% R
% Ser:
0
82
10
0
0
0
0
55
0
10
10
0
0
0
10
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% T
% Val:
0
0
10
0
0
0
46
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
19
0
0
10
0
10
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
55
0
0
0
0
19
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _