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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ADRA2C
All Species:
17.88
Human Site:
S257
Identified Species:
39.33
UniProt:
P18825
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P18825
NP_000674.2
462
49522
S257
P
V
G
P
D
G
A
S
P
T
T
E
N
G
L
Chimpanzee
Pan troglodytes
Q9N298
422
46153
G256
Q
P
K
K
S
V
N
G
E
S
G
S
R
N
W
Rhesus Macaque
Macaca mulatta
XP_001114432
408
42792
S255
P
V
G
P
D
G
A
S
P
T
T
E
N
G
L
Dog
Lupus familis
XP_545911
714
73976
S262
P
A
G
P
D
G
A
S
P
T
T
E
N
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q01337
458
49888
S257
P
A
G
P
D
G
A
S
P
T
T
E
N
G
L
Rat
Rattus norvegicus
P22086
458
49846
S257
P
A
G
P
D
G
A
S
P
T
T
E
N
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519776
218
24278
R72
R
A
V
E
Y
N
L
R
R
T
P
R
R
I
K
Chicken
Gallus gallus
XP_426355
614
69002
T417
M
P
E
G
S
S
Q
T
E
N
G
L
S
R
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q90WY6
432
49119
R255
L
S
R
E
D
S
R
R
E
N
G
H
C
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22270
601
64656
K315
K
L
N
T
I
A
L
K
S
T
E
L
E
P
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001200819
471
53401
N258
S
K
R
T
N
G
K
N
M
I
A
S
E
C
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
33.9
80.3
59.6
N.A.
92.8
93
N.A.
35.9
53.7
N.A.
58.4
N.A.
32.7
N.A.
N.A.
33.3
Protein Similarity:
100
50
80.9
61.6
N.A.
93.5
93.7
N.A.
39.1
60.2
N.A.
70.1
N.A.
47.5
N.A.
N.A.
52.2
P-Site Identity:
100
0
100
93.3
N.A.
93.3
93.3
N.A.
6.6
0
N.A.
6.6
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
6.6
100
93.3
N.A.
93.3
93.3
N.A.
6.6
13.3
N.A.
6.6
N.A.
20
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
37
0
0
0
10
46
0
0
0
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% C
% Asp:
0
0
0
0
55
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
19
0
0
0
0
28
0
10
46
19
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
46
10
0
55
0
10
0
0
28
0
0
46
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
0
10
0
0
0
10
10
% I
% Lys:
10
10
10
10
0
0
10
10
0
0
0
0
0
0
10
% K
% Leu:
10
10
0
0
0
0
19
0
0
0
0
19
0
0
46
% L
% Met:
10
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
10
10
10
10
0
19
0
0
46
10
0
% N
% Pro:
46
19
0
46
0
0
0
0
46
0
10
0
0
10
0
% P
% Gln:
10
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
10
0
19
0
0
0
10
19
10
0
0
10
19
10
0
% R
% Ser:
10
10
0
0
19
19
0
46
10
10
0
19
10
10
10
% S
% Thr:
0
0
0
19
0
0
0
10
0
64
46
0
0
0
0
% T
% Val:
0
19
10
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _